Evidence map›Paper›PMID 31235691›Full record

ArticleNature communications2019

Rearrangement of the transmembrane domain interfaces associated with the activation of a GPCR hetero-oligomer.

Li Xue, Qian Sun, Han Zhao, Xavier Rovira, Siyu Gai, Qianwen He, Jean-Philippe Pin, Jianfeng Liu, Philippe Rondard

Abstract read
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. GABA-independent activation of GABANature communications · 2025
    Article
  5. Structural Basis of GABAAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Impact of aging on the GABAbioRxiv : the preprint server for biology · 2024
    Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Characterization of aFrontiers in molecular neuroscience · 2023
    Article
  17. Article
  18. Article
  19. Myocardial TRPC6-mediated ZnNature communications · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Li XueCellular Signaling laboratory, International Research Center for Sensory Biology and Technology of MOST, Key Laboratory of Molecular Biophysics of MOE, and College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, Hubei, China.ORCID http://orcid.org/0000-0003-0650-2194
Qian SunCellular Signaling laboratory, International Research Center for Sensory Biology and Technology of MOST, Key Laboratory of Molecular Biophysics of MOE, and College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, Hubei, China.ORCID http://orcid.org/0000-0002-9532-3042
Han ZhaoCellular Signaling laboratory, International Research Center for Sensory Biology and Technology of MOST, Key Laboratory of Molecular Biophysics of MOE, and College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, Hubei, China.
Xavier RoviraInstitut de Génomique Fonctionnelle (IGF), CNRS, INSERM, Université de Montpellier, Montpellier, 34094 Montpellier cedex 05, France.
Siyu GaiCellular Signaling laboratory, International Research Center for Sensory Biology and Technology of MOST, Key Laboratory of Molecular Biophysics of MOE, and College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, Hubei, China.
Qianwen HeCellular Signaling laboratory, International Research Center for Sensory Biology and Technology of MOST, Key Laboratory of Molecular Biophysics of MOE, and College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, Hubei, China.
Jean-Philippe PinInstitut de Génomique Fonctionnelle (IGF), CNRS, INSERM, Université de Montpellier, Montpellier, 34094 Montpellier cedex 05, France. jean-philippe.pin@igf.cnrs.fr.ORCID http://orcid.org/0000-0002-1423-345X
Jianfeng LiuCellular Signaling laboratory, International Research Center for Sensory Biology and Technology of MOST, Key Laboratory of Molecular Biophysics of MOE, and College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, Hubei, China. jfliu@mail.hust.edu.cn.
Philippe RondardInstitut de Génomique Fonctionnelle (IGF), CNRS, INSERM, Université de Montpellier, Montpellier, 34094 Montpellier cedex 05, France.ORCID http://orcid.org/0000-0003-1134-2738

Funding

Agence Nationale de la Recherche (French National Research Agency) ANR-09-PIRI-0011Fondation pour la Recherche Médicale (Foundation for Medical Research in France) DEQ20130326522Fondation pour la Recherche Médicale (Foundation for Medical Research in France) DEQ20170336747
6 · The paper itself

Abstract

G protein-coupled receptors (GPCRs) can integrate extracellular signals via allosteric interactions within dimers and higher-order oligomers. However, the structural bases of these interactions remain unclear. Here, we use the GABA

Indexed as

Models, MolecularAllosteric RegulationAllosteric SiteCross-Linking ReagentsGABA-B Receptor Agonistsgamma-Aminobutyric AcidHEK293 CellsHumansProtein BindingProtein DomainsProtein MultimerizationReceptors, GABA-BCross-Linking ReagentsGABA-B Receptor Agonistsgamma-Aminobutyric AcidReceptors, GABA-B

Identifiers

PMID31235691
PMCPMC6591306

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.