Evidence map›Paper›PMID 31235656›Full record

ArticleGenome research2019

Early genome activation in

Jamie C Kwasnieski, Terry L Orr-Weaver, David P Bartel

Abstract read
In one paragraph

Article in Genome research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Regulation of zygotic genome activation by the nucleocytoplasmic ratio.Frontiers in cell and developmental biology · 2026
    Review
  8. Article
  9. Article
  10. Article
  11. Breaking anterior-posterior symmetry in the moth flybioRxiv : the preprint server for biology · 2025
    Article
  12. Article
  13. Review
  14. Article
  15. Quantifying Nascent Transcription in Early Embryogenesis.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  16. HIRA and dPCIF1 coordinately establish totipotent chromatin and control orderly ZGA inProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jamie C KwasnieskiHoward Hughes Medical Institute, Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA.
Terry L Orr-WeaverDepartment of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.ORCID 0000-0002-7934-111X
David P BartelHoward Hughes Medical Institute, Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA.

Funding

Post-transcriptional gene regulationR35GM118135 · NIGMS · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI DAVID P BARTEL · 2016 to 2026
$10.7M
Producing, provisioning, and protecting the egg: Regulation of DNA replication, mRNA translation, and proteolysis for the transition from oocyte to embryoR35GM118098 · NIGMS · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI ORR-WEAVER, TERRY L. · 2016 to 2018
$2.0M
Post-transcriptional gene regulation during early Drosophila developmentF32GM120984 · NIGMS · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI KWASNIESKI, JAMIE · 2016 to 2017
$115k
Howard Hughes Medical InstituteNIGMS NIH HHS F32 GM120984NIGMS NIH HHS R35 GM118098NIGMS NIH HHS R35 GM118135
6 · The paper itself

Abstract

Control of metazoan embryogenesis shifts from maternal to zygotic gene products as the zygotic genome becomes transcriptionally activated. In

Indexed as

Gene Expression Regulation, DevelopmentalGenome, InsectAnimalsDrosophilaFemaleIntronsRNA, MessengerTranscription, GeneticZygoteRNA, Messenger

Identifiers

PMID31235656
PMCPMC6633261

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.