Evidence map›Paper›PMID 31235626›Full record

ArticleAntimicrobial agents and chemotherapy2019

Structural Insights into the Inhibition of the Extended-Spectrum β-Lactamase PER-2 by Avibactam.

Melina Ruggiero, Krisztina M Papp-Wallace, Florencia Brunetti, Melissa D Barnes, Robert A Bonomo, Gabriel Gutkind, Sebastián Klinke, Pablo Power

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Microbiology spectrum · 2026
    Article
  3. Article
  4. Prevalence of ESBL-producingOne health (Amsterdam, Netherlands) · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Melina RuggieroUniversidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Departamento de Microbiología, Inmunología y Biotecnología, Laboratorio de Resistencia Bacteriana, Buenos Aires, Argentina.
Krisztina M Papp-WallaceMedical Service, Louis Stokes Cleveland VA Medical Center, Cleveland, Ohio, USA.
Florencia BrunettiUniversidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Departamento de Microbiología, Inmunología y Biotecnología, Laboratorio de Resistencia Bacteriana, Buenos Aires, Argentina.
Melissa D BarnesMedical Service, Louis Stokes Cleveland VA Medical Center, Cleveland, Ohio, USA.
Robert A BonomoMedical Service, Louis Stokes Cleveland VA Medical Center, Cleveland, Ohio, USA.
Gabriel GutkindUniversidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Departamento de Microbiología, Inmunología y Biotecnología, Laboratorio de Resistencia Bacteriana, Buenos Aires, Argentina.
Sebastián Klinke *Fundación Instituto Leloir, IIBBA-CONICET, Buenos Aires, Argentina sklinke@leloir.org.ar ppower@ffyb.uba.ar.ORCID 0000-0002-8777-0870
Pablo Power *Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Departamento de Microbiología, Inmunología y Biotecnología, Laboratorio de Resistencia Bacteriana, Buenos Aires, Argentina sklinke@leloir.org.ar ppower@ffyb.uba.ar.ORCID 0000-0002-7051-9954

Funding

Understanding B-Lactam Resistance in Acinetobacter baumanniiR01AI072219 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI ROBERT A. BONOMO, Philip N. Rather · 2007 to 2026
$6.6M
Understanding ceftazidime resistance in SHV B-LactamasesR01AI063517 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI BONOMO, ROBERT A. · 2005 to 2023
$4.9M
A Mechanism-Based Approach to Metallo-beta-Lactamase InhibitionR01AI100560 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI BONOMO, ROBERT A., SPENCER, JAMES · 2012 to 2022
$4.4M
Molecular Epidemiology of Carbapenem-Resistant Klebsiella pneumoniaeR21AI114508 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI BONOMO, ROBERT A., VAN DUIN, DAVID · 2015 to 2016
$445k
The Continuing Challenge of Carbapenemases in K. pneumoniae: KPC-2 & NDM-1I01BX001974 · VA · LOUIS STOKES CLEVELAND VA MEDICAL CENTER · PI BONOMO, ROBERT A. · 2013 to 2024
–
Targeting Burkholderial β-lactamases: Structure, function, and regulationI01BX002872 · VA · LOUIS STOKES CLEVELAND VA MEDICAL CENTER · PI DONSKEY, CURTIS, PAPP-WALLACE, KRISZTINA MARGARET · 2016 to 2023
–
BLRD VA I01 BX001974BLRD VA I01 BX002872NIAID NIH HHS R01 AI063517NIAID NIH HHS R01 AI072219NIAID NIH HHS R01 AI100560NIAID NIH HHS R21 AI114508
6 · The paper itself

Abstract

The diazabicyclooctane (DBO) avibactam (AVI) reversibly inactivates most serine-β-lactamases. Previous investigations showed that inhibition constants of AVI toward class A PER-2 are reminiscent of values observed for class C and D β-lactamases (i.e.,

Indexed as

Amino Acid SubstitutionArginineAzabicyclo Compoundsbeta-Lactamase Inhibitorsbeta-LactamasesCatalytic DomainEscherichia coliMicrobial Sensitivity TestsModels, MolecularMutationProtein ConformationArginineavibactamAzabicyclo Compoundsbeta-Lactamase Inhibitorsbeta-lactamase PER-2, Enterobacteriaceaebeta-lactamase PIT-2beta-LactamasesDBOβ-lactamβ-lactamaseβ-lactamase inhibitor

Identifiers

PMID31235626
PMCPMC6709463

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.