Evidence map›Paper›PMID 31235622›Full record

ArticleAntimicrobial agents and chemotherapy2019

Disruption of Membrane Integrity by the Bacterium-Derived Antifungal Jagaricin.

Daniel Fischer, Guido Gessner, Taicia Pacheco Fill, Robert Barnett, Kyrylo Tron, Katharina Dornblut, Florian Kloss, Pierre Stallforth, Bernhard Hube, Stefan H Heinemann and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.4field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 25 citations in OpenAlex.

  1. Heritable symbiont producing nonribosomal peptide confers extreme heat sensitivity and antifungal protection on its host.Proceedings of the National Academy of Sciences of the United States of America · 2025
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  9. Journal of fungi (Basel, Switzerland) · 2022
    Article
  10. Review
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  12. Review
  13. Review
  14. Article
  15. Helper bacteria halt and disarm mushroom pathogens by linearizing structurally diverse cyclolipopeptides.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Daniel FischerDepartment of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knöll Institute, Jena, Germany.
Guido GessnerCenter for Molecular Biomedicine, Department of Biophysics, Friedrich Schiller University Jena and Jena University Hospital, Jena, Germany.
Taicia Pacheco FillDepartment of Biomolecular Chemistry, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knöll Institute, Jena, Germany.
Robert BarnettJunior Research Group Chemistry of Microbial Communication, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knöll Institute, Jena, Germany.
Kyrylo TronCenter for Molecular Biomedicine, Department of Biophysics, Friedrich Schiller University Jena and Jena University Hospital, Jena, Germany.
Katharina DornblutDepartment of Biomolecular Chemistry, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knöll Institute, Jena, Germany.
Florian KlossTransfer Group Antiinfectives, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knöll Institute, Jena, Germany.
Pierre StallforthJunior Research Group Chemistry of Microbial Communication, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knöll Institute, Jena, Germany.
Bernhard HubeDepartment of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knöll Institute, Jena, Germany.ORCID 0000-0002-6028-0425
Stefan H HeinemannCenter for Molecular Biomedicine, Department of Biophysics, Friedrich Schiller University Jena and Jena University Hospital, Jena, Germany.
Christian HertweckDepartment of Biomolecular Chemistry, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knöll Institute, Jena, Germany.
Kirstin ScherlachDepartment of Biomolecular Chemistry, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knöll Institute, Jena, Germany kirstin.scherlach@leibniz-hki.de sascha.brunke@leibniz-hki.de.
Sascha BrunkeDepartment of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knöll Institute, Jena, Germany kirstin.scherlach@leibniz-hki.de sascha.brunke@leibniz-hki.de.ORCID 0000-0001-7740-4570
Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI) · DEJena University Hospital · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Jagaricin is a lipopeptide produced by the bacterial mushroom pathogen

Indexed as

Antifungal AgentsCalciumCandida albicansCandida glabrataCandidiasisCell MembraneFungal ProteinsGene Expression Regulation, FungalHEK293 CellsHumansMicrobial Sensitivity TestsMutationPeptides, CyclicAntifungal AgentsCalciumFungal ProteinsjagaricinPeptides, Cycliccalcium influxCandida albicansjagaricinmembrane integritymode of actionpathogenic fungisusceptibility testing

Identifiers

PMID31235622
PMCPMC6709453
OpenAlexW2949336936

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.