Evidence map›Paper›PMID 31235617›Full record

ArticleJournal of the American Society of Nephrology : JASN2019

Impact of AKI on Urinary Protein Excretion: Analysis of Two Prospective Cohorts.

Chi-Yuan Hsu, Raymond K Hsu, Kathleen D Liu, Jingrong Yang, Amanda Anderson, Jing Chen, Vernon M Chinchilli, Harold I Feldman, Amit X Garg, Lee Hamm and 14 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of the American Society of Nephrology : JASN, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Black and White Adults With CKD Hospitalized With Acute Kidney Injury: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2022
    Article
  15. Article
  16. Article
  17. Article
  18. Individualized acute kidney injury after care.Current opinion in critical care · 2020
    Review
  19. Improving Care for Patients after Hospitalization with AKI.Journal of the American Society of Nephrology : JASN · 2020
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 16 institutions in 2 countries.

Chi-Yuan HsuDepartment of Medicine, University of California, San Francisco, San Francisco, California; hsuchi@medicine.ucsf.edu.
Raymond K HsuDepartment of Medicine, University of California, San Francisco, San Francisco, California.
Kathleen D LiuDepartment of Medicine, University of California, San Francisco, San Francisco, California.
Jingrong YangDivision of Research, Kaiser Permanente Northern California, Oakland, California.
Amanda AndersonDepartments of Epidemiology and.
Jing ChenMedicine, Tulane University, New Orleans, Louisiana.
Vernon M ChinchilliDepartment of Public Health Sciences, Penn State College of Medicine, Hershey, Pennsylvania.
Harold I FeldmanDepartment of Biostatistics and Epidemiology, and.
Amit X GargDepartment of Medicine, Western University, London, Ontario, Canada.
Lee HammMedicine, Tulane University, New Orleans, Louisiana.
Jonathan HimmelfarbDepartment of Medicine, University of Washington, Seattle, Washington.
James S KaufmanVeterans Affairs New York Harbor Healthcare System, New York, New York.
John W KusekDepartment of Biostatistics and Epidemiology, and.
Chirag R ParikhDepartment of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland.
Ana C RicardoDepartment of Medicine, University of Illinois, Chicago, Illinois.
Sylvia E RosasKidney and Hypertension Unit, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts.
Georges SaabCase Western Reserve University and Metrohealth Medical Center, Cleveland, Ohio.
Daohang ShaCenter for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania.
Edward D SiewVanderbilt University Medical Center and Nashville Veterans Affairs Hospital, Nashville, Tennessee.
James SondheimerDepartment of Medicine, Wayne State University School of Medicine, Detroit, Michigan; and.ORCID 0000-0002-9538-9682
Jonathan J TaliercioCleveland Clinic, Cleveland, Ohio.
Wei YangDepartment of Biostatistics and Epidemiology, and.
Alan S GoDepartment of Medicine, University of California, San Francisco, San Francisco, California.
Chronic Renal Insufficiency Cohort (CRIC) Study Investigators and the Assessment, Serial Evaluation, and Subsequent Sequelae of Acute Kidney Injury (ASSESS-AKI) Study
Cancer Research And Biostatistics · USKaiser Permanente · USTulane University · USUniversity of California, San Francisco · USCleveland Clinic · USJohns Hopkins University · USJoslin Diabetes Center · USMetroHealth Medical Center · USPennsylvania State University · USUniversity of Illinois Chicago · USUniversity of Pennsylvania · USUniversity of Washington · USVanderbilt University Medical Center · USVA NY Harbor Healthcare System · USWayne State University · USWestern University · CA

Funding

UCSF CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024131 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$111.2M
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Tracking & Evaluation CoreU54GM104940 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Leigh Lamonica · 2012 to 2026
$69.1M
Scientific and Data Coordinating Center(SDCC) for the P*U01DK060990 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI FELDMAN, HAROLD I · 2001 to 2017
$50.1M
Clinical and Translational Science Collaborative of ClevelandUL1TR000439 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$50.0M
Michigan Institute for Clinical and Health Research (MCHR)UL1TR000433 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MASHOUR, GEORGE ALEXANDER · 2012 to 2016
$49.9M
Institutional Clinical and Translational Science AwardUL1TR000003 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2012 to 2015
$38.9M
Clinical and Translational Science Collaborative of ClevelandUL1TR002548 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI MCCOMSEY, GRACE A · 2018 to 2022
$35.5M
Strengthening Stakeholder Engagement in Human Research Protections.UL1TR002003 · NCATS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KARNIK, NIRANJAN SUBHASH, MERMELSTEIN, ROBIN J. · 2016 to 2024
$33.7M
Tulane COBRE in Cardiometabolic Diseases Clinical Research CoreP20GM109036 · NIGMS · TULANE UNIVERSITY OF LOUISIANA · PI Ning Liu · 2016 to 2026
$25.3M
Continuation of the Coordinating Center for the Chronic Renal Insufficiency Cohort (CRIC) StudyU24DK060990 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Amanda Hyre Anderson, Laura M Dember · 2018 to 2026
$21.5M
Zonulin Antibodies in Intestinal Permeabilitiy in IDDMM01RR016500 · NCRR · UNIVERSITY OF MARYLAND BALTIMORE · PI ONUKWUGHA, EBERECHUKWU · 2002 to 2009
$20.2M
CIHRNCATS NIH HHS UL1 TR000003NCATS NIH HHS UL1 TR000424NCATS NIH HHS UL1 TR000433NCATS NIH HHS UL1 TR000439NCATS NIH HHS UL1 TR001863NCATS NIH HHS UL1 TR002003NCATS NIH HHS UL1 TR002548NCRR NIH HHS M01 RR013987NCRR NIH HHS M01 RR016500NCRR NIH HHS UL1 RR024131NCRR NIH HHS UL1 RR029879NIDDK NIH HHS K23 DK100468NIDDK NIH HHS R01 DK072231NIDDK NIH HHS R01 DK098233NIDDK NIH HHS R01 DK101507NIDDK NIH HHS R01 DK114014NIDDK NIH HHS R01 DK139225NIDDK NIH HHS R03 DK111881NIDDK NIH HHS U01 DK060902NIDDK NIH HHS U01 DK060963NIDDK NIH HHS U01 DK060980NIDDK NIH HHS U01 DK060984NIDDK NIH HHS U01 DK060990NIDDK NIH HHS U01 DK061021NIDDK NIH HHS U01 DK061022NIDDK NIH HHS U01 DK061028NIDDK NIH HHS U01 DK082183NIDDK NIH HHS U01 DK082185NIDDK NIH HHS U01 DK082192NIDDK NIH HHS U01 DK082223NIDDK NIH HHS U01 DK084012NIDDK NIH HHS U24 DK060990NIGMS NIH HHS P20 GM109036NIGMS NIH HHS U54 GM104940
6 · The paper itself

Abstract

backgroundPrior studies of adverse renal consequences of AKI have almost exclusively focused on eGFR changes. Less is known about potential effects of AKI on proteinuria, although proteinuria is perhaps the strongest risk factor for future loss of renal function.

methodsWe studied enrollees from the Assessment, Serial Evaluation, and Subsequent Sequelae of AKI (ASSESS-AKI) study and the subset of the Chronic Renal Insufficiency Cohort (CRIC) study enrollees recruited from Kaiser Permanente Northern California. Both prospective cohort studies included annual ascertainment of urine protein-to-creatinine ratio, eGFR, BP, and medication use. For hospitalized participants, we used inpatient serum creatinine measurements obtained as part of clinical care to define an episode of AKI (

resultsAt cohort entry, median eGFR was 62.9 ml/min per 1.73 m

conclusionsOur analysis of data from two prospective cohort studies found that hospitalization for an AKI episode was independently associated with subsequent worsening of proteinuria.

Indexed as

Acute Kidney InjuryAdolescentAdultAgedAged, 80 and overCreatinineGlomerular Filtration RateHospitalizationHumansMiddle AgedProspective StudiesProteinuriaYoung AdultCreatinineacute renal failureproteinuriarenal injury

Identifiers

PMID31235617
PMCPMC6622423
OpenAlexW2953492042

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.