Evidence map›Paper›PMID 31235604›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Enabling microbial syringol conversion through structure-guided protein engineering.

Melodie M Machovina, Sam J B Mallinson, Brandon C Knott, Alexander W Meyers, Marc Garcia-Borràs, Lintao Bu, Japheth E Gado, April Oliver, Graham P Schmidt, Daniel J Hinchen and 8 more

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 65 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Obtaining PDC and other high-added value products from lignin byJournal of integrative bioinformatics · 2025
    Article
  5. Article
  6. Article
  7. The catabolism of lignin-derivedApplied and environmental microbiology · 2024
    Article
  8. Article
  9. A keyApplied and environmental microbiology · 2023
    Article
  10. Draft Genome Assembly ofMicrobiology resource announcements · 2023
    Article
  11. Article
  12. Allyl Aryl Ether Cleavage byMicrobiology spectrum · 2022
    Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Cytochromes P450 in the biocatalytic valorization of lignin.Current opinion in biotechnology · 2022
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 7 institutions in 2 countries.

Melodie M MachovinaDepartment of Chemistry and Biochemistry, Montana State University, Bozeman, MT 59717.
Sam J B MallinsonCentre for Enzyme Innovation, School of Biological Sciences, Institute of Biological and Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2UP, United Kingdom.
Brandon C KnottBiosciences Center, National Renewable Energy Laboratory, Golden, CO 80401.
Alexander W MeyersNational Bioenergy Center, National Renewable Energy Laboratory, Golden, CO 80401.
Marc Garcia-BorràsDepartment of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095.ORCID 0000-0001-9458-1114
Lintao BuBiosciences Center, National Renewable Energy Laboratory, Golden, CO 80401.
Japheth E GadoNational Bioenergy Center, National Renewable Energy Laboratory, Golden, CO 80401.
April OliverDepartment of Chemistry and Biochemistry, Montana State University, Bozeman, MT 59717.
Graham P SchmidtBiosciences Center, National Renewable Energy Laboratory, Golden, CO 80401.
Daniel J HinchenCentre for Enzyme Innovation, School of Biological Sciences, Institute of Biological and Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2UP, United Kingdom.
Michael F CrowleyBiosciences Center, National Renewable Energy Laboratory, Golden, CO 80401.
Christopher W JohnsonNational Bioenergy Center, National Renewable Energy Laboratory, Golden, CO 80401.ORCID 0000-0002-2979-4751
Ellen L NeidleDepartment of Microbiology, University of Georgia, Athens, GA 30602.ORCID 0000-0003-1665-5303
Christina M PayneDepartment of Chemical Engineering, University of Kentucky, Lexington, KY 40506.ORCID 0000-0001-5264-0964
Kendall N HoukDepartment of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095; houk@chem.ucla.edu gregg.beckham@nrel.gov john.mcgeehan@port.ac.uk jennifer.dubois1@montana.edu.
Gregg T BeckhamNational Bioenergy Center, National Renewable Energy Laboratory, Golden, CO 80401; houk@chem.ucla.edu gregg.beckham@nrel.gov john.mcgeehan@port.ac.uk jennifer.dubois1@montana.edu.ORCID 0000-0002-3480-212X
John E McGeehanCentre for Enzyme Innovation, School of Biological Sciences, Institute of Biological and Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2UP, United Kingdom; houk@chem.ucla.edu gregg.beckham@nrel.gov john.mcgeehan@port.ac.uk jennifer.dubois1@montana.edu.ORCID 0000-0002-6750-1462
Jennifer L DuBoisDepartment of Chemistry and Biochemistry, Montana State University, Bozeman, MT 59717; houk@chem.ucla.edu gregg.beckham@nrel.gov john.mcgeehan@port.ac.uk jennifer.dubois1@montana.edu.
National Laboratory of the Rockies · USMontana State University · USUniversity of Portsmouth · GBUniversity of California, Los Angeles · USOak Ridge National Laboratory · USUniversity of Georgia · USUniversity of Kentucky · US

Funding

Biotechnology and Biological Sciences Research Council BB/L001926/1Biotechnology and Biological Sciences Research Council BB/P011918/1
6 · The paper itself

Abstract

Microbial conversion of aromatic compounds is an emerging and promising strategy for valorization of the plant biopolymer lignin. A critical and often rate-limiting reaction in aromatic catabolism is

Indexed as

Protein EngineeringCytochrome P-450 Enzyme SystemLigninMethylationOxidation-ReductionOxidoreductases, O-DemethylatingPseudomonas putidaPyrogallolCytochrome P-450 Enzyme SystemLigninOxidoreductases, O-DemethylatingPyrogallolpyrogallol 1,3-dimethyl etherbiorefinerydemethylaseligninP450

Identifiers

PMID31235604
PMCPMC6628648
OpenAlexW2953161702

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.