ArticleProceedings of the National Academy of Sciences of the United States of America2019
Cochlear partition anatomy and motion in humans differ from the classic view of mammals.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Displacement gradients in the lateral region of the organ of Corti dissipate power in the cochlea.Biophysical journal · 2026Article
- Anatomical Integrity of the Human Cochlea Estimated with Optical Coherence Tomography for Future Clinical Application.Journal of the Association for Research in Otolaryngology : JARO · 2026Article
- Anatomical integrity of the human cochlea estimated with optical coherence tomography for future clinical application.bioRxiv : the preprint server for biology · 2025Article
- Volume rendering technique and high-resolution microCT: 3D exploration of the cochlear anatomy.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Article
- How the Human Cochlea Moves: Biomechanical Modeling of a Wide, Layered Osseous Spiral Lamina.Journal of the Association for Research in Otolaryngology : JARO · 2025Article
- 3D Computational Modeling of Blast Transmission through the Fluid-Filled Cochlea and Hair Cells.Annals of biomedical engineering · 2025Article
- Cochlear Apex Triangulation Utilizing Ct Measures And Middle Ear Landmarks.Otology & neurotology open · 2024Article
- Microanatomy of the human tunnel of Corti structures and cochlear partition-tonotopic variations and transcellular signaling.Journal of anatomy · 2024Article
- Quantitative Evaluation of the 3D Anatomy of the Human Osseous Spiral Lamina Using MicroCT.Journal of the Association for Research in Otolaryngology : JARO · 2023Article
- Three-dimensional quantification of fibrosis and ossification after cochlear implantation via virtual re-sectioning: Potential implications for residual hearing.Hearing research · 2023Article
- Optical Coherence Tomography-Based Atlas of the Human Cochlear Hook Region.Journal of clinical medicine · 2022Article
- Cochlear Amplification in the Short-Wave Region by Outer Hair Cells changing Organ-of-Corti area to Amplify the Fluid Traveling Wave.Hearing research · 2022Article
- Overturning the mechanisms of cochlear amplification via area deformations of the organ of Corti.The Journal of the Acoustical Society of America · 2022Article
- Otosclerosis under microCT: New insights into the disease and its anatomy.Frontiers in radiology · 2022Article
- Experimental Validation of a Three-Dimensional Heat Transfer Model Within the Scala Tympani With Application to Magnetic Cochlear Implant Surgery.IEEE transactions on bio-medical engineering · 2021Article
- Nonlinearity of intracochlear motion and local cochlear microphonic: Comparison between guinea pig and gerbil.Hearing research · 2021Article
- Inner hair cell stereocilia are embedded in the tectorial membrane.Nature communications · 2021Article
- Anatomy of the Human Osseous Spiral Lamina and Cochlear Partition Bridge: Relevance for Cochlear Partition Motion.Journal of the Association for Research in Otolaryngology : JARO · 2020Article
- The Correlation of a 2D Volume-Referencing Endolymphatic-Hydrops Grading System With Extra-Tympanic Electrocochleography in Patients With Definite Ménière's Disease.Frontiers in neurology · 2020Article
- Cochlear shape reveals that the human organ of hearing is sex-typed from birth.Scientific reports · 2019Article
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Authors and funding
3 authors.
Funding
Abstract
Mammals detect sound through mechanosensitive cells of the cochlear organ of Corti that rest on the basilar membrane (BM). Motions of the BM and organ of Corti have been studied at the cochlear base in various laboratory animals, and the assumption has been that the cochleas of all mammals work similarly. In the classic view, the BM attaches to a stationary osseous spiral lamina (OSL), the tectorial membrane (TM) attaches to the limbus above the stationary OSL, and the BM is the major moving element, with a peak displacement near its center. Here, we measured the motion and studied the anatomy of the human cochlear partition (CP) at the cochlear base of fresh human cadaveric specimens. Unlike the classic view, we identified a soft-tissue structure between the BM and OSL in humans, which we name the CP "bridge." We measured CP transverse motion in humans and found that the OSL moved like a plate hinged near the modiolus, with motion increasing from the modiolus to the bridge. The bridge moved almost as much as the BM, with the maximum CP motion near the bridge-BM connection. BM motion accounts for 100% of CP volume displacement in the classic view, but accounts for only 27 to 43% in the base of humans. In humans, the TM-limbus attachment is above the moving bridge, not above a fixed structure. These results challenge long-held assumptions about cochlear mechanics in humans. In addition, animal apical anatomy (in
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