Evidence map›Paper›PMID 31235565›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

The sRNA DicF integrates oxygen sensing to enhance enterohemorrhagic

Elizabeth M Melson, Melissa M Kendall

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 50 citations in OpenAlex.

  1. EnterohemorrhagicmSystems · 2026
    Article
  2. EnterohemorrhagiciScience · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. ThemSphere · 2024
    Article
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  15. Article
  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Elizabeth M MelsonDepartment of Microbiology, Immunology and Cancer Biology, University of Virginia School of Medicine, Charlottesville, VA 22908.
Melissa M KendallDepartment of Microbiology, Immunology and Cancer Biology, University of Virginia School of Medicine, Charlottesville, VA 22908 melissakendall@virginia.edu.
University of Virginia · US

Funding

INFECTIOUS DISEASES TRAINING PROGRAMT32AI007046 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Alison K Criss, William A Petri · 1985 to 2026
$15.3M
Ethanolamine Signaling in Virulence Gene Regulation and Host/Microbial InteractionsR01AI118732 · NIAID · UNIVERSITY OF VIRGINIA · PI KENDALL, MELISSA · 2015 to 2019
$1.9M
Mechanisms involved in Salmonella immune evasionR21AI130439 · NIAID · UNIVERSITY OF VIRGINIA · PI KENDALL, MELISSA · 2018 to 2019
$437k
NIAID NIH HHS R01 AI118732NIAID NIH HHS R21 AI130439NIAID NIH HHS T32 AI007046
6 · The paper itself

Abstract

To establish infection, enteric pathogens integrate environmental cues to navigate the gastrointestinal tract (GIT) and precisely control expression of virulence determinants. During passage through the GIT, pathogens encounter relatively high levels of oxygen in the small intestine before transit to the oxygen-limited environment of the colon. However, how bacterial pathogens sense oxygen availability and coordinate expression of virulence traits is not resolved. Here, we demonstrate that enterohemorrhagic

Indexed as

Enterohemorrhagic Escherichia coliEscherichia coli InfectionsEscherichia coli O157Escherichia coli ProteinsGastrointestinal TractGene Expression Regulation, BacterialHumansOxygenRibosomesRNATranscription FactorsVirulenceVirulence FactorsEscherichia coli ProteinsOxygenpchA protein, E coliRNATranscription FactorsVirulence FactorsEHECintestineoxygenpathogenesissRNA

Identifiers

PMID31235565
PMCPMC6628830
OpenAlexW2954860142

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.