ArticleThe Journal of experimental medicine2019
Loss of the interleukin-6 receptor causes immunodeficiency, atopy, and abnormal inflammatory responses.
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In one paragraph
Article in The Journal of experimental medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 121 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
121citing papers in PubMed, 2 pooled it
10.3field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
121 citing papers in PubMed, 2 syntheses or guidelines pooled it, 201 citations in OpenAlex.
- The role of chemokines and interleukins in acute lymphoblastic leukemia: a systematic review.Journal of applied biomedicine · 2024Pooled it
- Effects ofFrontiers in genetics · 2022Pooled it
- Impaired angiogenesis and extracellular matrix metabolism in autosomal-dominant hyper-IgE syndrome.The Journal of clinical investigation · 2020Trial
- Refining therapeutic targeting of interleukin-6 by signalling mode selectivity.Nature reviews. Drug discovery · 2026Review
- Autosomal recessive OSMRβ deficiency: Connecting OSM and/or IL-31 with atopy.Journal of human immunity · 2026Article
- Cytokine multimerization: when more is more and sometimes less.Nature reviews. Immunology · 2026Review
- Clinical features, genetics, treatment, and long-term outcomes of STAT3 hyper-IgE syndrome: Single-center cohort analysis.The Journal of allergy and clinical immunology · 2026Observational
- Primary atopic disorders: Monogenic insights into immunity.Journal of human immunity · 2026Review
- Bridging Rare to Common Diseases: Precision Medicine and the Transforming Landscape of Pediatric Allergy and Immunology.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026Review
- Oncostatin M receptor deficiency as a novel candidate genetic cause of autosomal recessive hyper-IgE syndrome.Journal of human immunity · 2026Article
- Tonsillar expression quantitative trait loci verify and expand genetic contributors to childhood atopic diseases.bioRxiv : the preprint server for biology · 2026Article
- Perinatal exposure to the environmental pollutant butyl benzyl phthalate (BBP) induces sex-specific alterations in the neuro-immune-endocrine network in adult rats.Frontiers in immunology · 2026Article
- Review
- Targeting IL-6 Signaling: Safety and Effectiveness in Older Patients with Rheumatoid Arthritis.Drugs & aging · 2025Review
- Pathological IgE Production in Inborn Errors of Immunity and Beyond.Immunological reviews · 2025Review
- RNase 7 and Th cytokines synergistically increase the secretion of interleukin-6 from keratinocytes.Scientific reports · 2025Article
- The monogenic landscape of human infectious diseases.The Journal of allergy and clinical immunology · 2025Review
- Inborn Errors of Immunity Presenting with Early-Onset Severe Atopy.Medicina (Kaunas, Lithuania) · 2025Review
- Atopic dermatitis, primary atopic disorders, and the cutaneous microbiome: current understanding of an expanding field.Frontiers in pediatrics · 2025Review
- Cytokine signaling defects in primary atopic diseases-an updated review.Frontiers in allergy · 2025Review
61 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
38 authors at 8 institutions in 4 countries.
Sarah Spencer *Medical Research Council Toxicology Unit, University of Cambridge, Cambridge, UK.ORCID 0000-0002-8989-1553
Sevgi Köstel Bal *Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria.ORCID 0000-0002-3718-5323
William Egner *Sheffield Teaching Hospitals National Health Service Trust, Sheffield, UK.
Hana Lango Allen *Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.ORCID 0000-0002-7803-8688
Syed I Raza *Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
Chi A Ma *Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.
Meltem Gürel *Cancer Research UK Cambridge Institute, Cambridge Biomedical Campus, Cambridge, UK.
Yuan Zhang *Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.ORCID 0000-0001-9932-917X
Guangping Sun *Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.
Ruth A SabroeDepartment of Dermatology, Sheffield Teaching Hospitals National Health Service Trust, Sheffield, UK.
Daniel GreeneDepartment of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.
William RaeDepartment of Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.
Tala ShahinLudwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria.
Katarzyna KaniaCancer Research UK Cambridge Institute, Cambridge Biomedical Campus, Cambridge, UK.ORCID 0000-0001-8206-1349
Rico Chandra ArdyLudwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria.ORCID 0000-0003-4975-2177
Marini ThianLudwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria.ORCID 0000-0002-3016-0430
Emily StaplesDepartment of Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.
Annika Pecchia-BekkumDepartment of Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.
William P M WorrallDepartment of Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.ORCID 0000-0003-2507-8173
Jonathan StephensDepartment of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.
Matthew BrownDepartment of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.
Salih TunaDepartment of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.
Melanie YorkSheffield Teaching Hospitals National Health Service Trust, Sheffield, UK.ORCID 0000-0002-1522-9073
Fiona ShackleySheffield Teaching Hospitals National Health Service Trust, Sheffield, UK.
Diarmuid KerrinBarnsley Hospitals National Health Service Foundation Trust, Barnsley, UK.
Ravishankar SargurSheffield Teaching Hospitals National Health Service Trust, Sheffield, UK.ORCID 0000-0002-8535-630X
Alison CondliffeSheffield Teaching Hospitals National Health Service Trust, Sheffield, UK.ORCID 0000-0002-6697-8648
Hamid Nawaz TipuImmunology Department, Armed Forces Institute of Pathology, Rawalpindi, Pakistan.ORCID 0000-0003-0105-103X
Hye Sun KuehnDepartment of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD.
Sergio D RosenzweigDepartment of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD.
Ernest TurroDepartment of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.ORCID 0000-0002-1820-6563
Simon TavaréCancer Research UK Cambridge Institute, Cambridge Biomedical Campus, Cambridge, UK.ORCID 0000-0002-3716-4952
Adrian J ThrasherMolecular and Cellular Immunology Section, University College London Great Ormond Street Institute of Child Health, Great Ormond Street Hospital National Health Service Trust, London, UK.ORCID 0000-0002-6097-6115
Duncan Ian JodrellDepartment of Oncology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.ORCID 0000-0001-9360-1670
Kenneth G C SmithDepartment of Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.ORCID 0000-0003-3829-4326
Kaan Boztug *Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria kaan.boztug@rud.lbg.ac.at.ORCID 0000-0001-8387-9185
Joshua D Milner *Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD joshua.milner@nih.gov.ORCID 0000-0002-3913-3869
James E D Thaventhiran *Medical Research Council Toxicology Unit, University of Cambridge, Cambridge, UK jedt2@cam.ac.uk.ORCID 0000-0001-8616-074X
National Health Service · GBUniversity of Cambridge · GBAustrian Academy of Sciences · ATNational Institutes of Health · USCancer Research UK Cambridge Center · GBNational Institutes of Health Clinical Center · USArmed Forces Institute of Pathology · PKQuaid-i-Azam University · PK
Funding
Studies of Inherited Causes of Fungal SusceptabilityZIAAI001122 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI ROSENZWEIG, SERGIO · 2010 to 2025
$26.0MGenetic and Pathophysiologic Study of Atopic DiseaseZIAAI001183 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI MILNER, JOSHUA · 2013 to 2019
$8.7MPathogenesis and Treatment of Atopic DermatitisZIAAI001098 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI MILNER, JOSHUA · 2009 to 2019
$6.5MMutation Analysis Of Selected Lymphoid Immune DisordersZIACL010304 · CLC · CLINICAL CENTER · PI ROSENZWEIG, SERGIO · 2009 to 2025
$0kAustrian Science Fund FWF P 29951Cancer Research UK 15678Cancer Research UK 20406Intramural NIH HHS ZIA AI001098Medical Research Council MC_EX_MR/S300011/1Medical Research Council MR/L006197/1Medical Research Council MR/L019027/1Wellcome Trust
Abstract
IL-6 excess is central to the pathogenesis of multiple inflammatory conditions and is targeted in clinical practice by immunotherapy that blocks the IL-6 receptor encoded by
Indexed as
AdolescentAdultChildChild, PreschoolFemaleHEK293 CellsHumansImmunologic Deficiency SyndromesInfant, NewbornInflammationMaleReceptors, Interleukin-6Receptors, Interleukin-6
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.