Evidence map›Paper›PMID 31235478›Full record

ArticleMolecular and cellular biology2019

MicroRNA (miRNA)-to-miRNA Regulation of Programmed Cell Death 4 (PDCD4).

Pamela Ajuyah, Meredith Hill, Alireza Ahadi, Jing Lu, Gyorgy Hutvagner, Nham Tran

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular and cellular biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. miR-21 in Human Cardiomyopathies.Frontiers in cardiovascular medicine · 2021
    Review
  11. Article
  12. Clinical significance and potential mechanisms ofOpen medicine (Warsaw, Poland) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Pamela AjuyahSchool of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia.
Meredith HillSchool of Biomedical Engineering, Faculty of Engineering and Information Technology, University of Technology Sydney, Sydney, NSW, Australia.ORCID 0000-0003-4637-1483
Alireza AhadiSchool of Biomedical Engineering, Faculty of Engineering and Information Technology, University of Technology Sydney, Sydney, NSW, Australia.
Jing LuSchool of Biomedical Engineering, Faculty of Engineering and Information Technology, University of Technology Sydney, Sydney, NSW, Australia.
Gyorgy HutvagnerSchool of Biomedical Engineering, Faculty of Engineering and Information Technology, University of Technology Sydney, Sydney, NSW, Australia.
Nham TranSchool of Biomedical Engineering, Faculty of Engineering and Information Technology, University of Technology Sydney, Sydney, NSW, Australia nham.tran@uts.edu.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The regulation of tumor suppressor genes by microRNAs (miRNAs) is often demonstrated as a one-miRNA-to-one-target relationship. However, given the large number of miRNA sites within a 3' untranslated region (UTR), most targets likely undergo miRNA cooperation or combinatorial action. Programmed cell death 4 (PDCD4), an important tumor suppressor, prevents neoplastic events and is commonly downregulated in cancer. This study investigates the relationship between miRNA 21 (miR-21) and miR-499 in regulating PDCD4. This was explored using miRNA overexpression, mutational analysis of the PDCD4 3' UTR to assess regulation at each miRNA site, and 50% inhibitory concentration (IC

Indexed as

3' Untranslated RegionsApoptosis Regulatory ProteinsBinding SitesCell Line, TumorDown-RegulationGene Expression Regulation, NeoplasticHead and Neck NeoplasmsHEK293 CellsHeLa CellsHumansMicroRNAsMutationProtein BindingRNA-Binding ProteinsSquamous Cell Carcinoma of Head and Neck3' Untranslated RegionsApoptosis Regulatory ProteinsMicroRNAsMIRN21 microRNA, humanMIRN499 microRNA, humanPDCD4 protein, humanRNA-Binding Proteinscancer biologycooperative regulationgene silencinghead and neck squamous cell carcinomaHNSCCmicroRNAmiRNA

Identifiers

PMID31235478
PMCPMC6712940

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.