Evidence map›Paper›PMID 31235476›Full record

ArticleLife science alliance2019

An unusual and vital protein with guanylate cyclase and P4-ATPase domains in a pathogenic protist.

Özlem Günay-Esiyok, Ulrike Scheib, Matthias Noll, Nishith Gupta

Open access · goldAbstract read
In one paragraph

Article in Life science alliance, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
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  6. Orthologs ofMicrobiology spectrum · 2024
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  15. Plasticity and therapeutic potential of cAMP and cGMP-specific phosphodiesterases inComputational and structural biotechnology journal · 2022
    Article
  16. mBio · 2021
    Article
  17. Article
  18. Article
  19. The protozoan parasiteComputational and structural biotechnology journal · 2020
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Özlem Günay-EsiyokInstitute of Biology, Faculty of Life Sciences, Humboldt University, Berlin, Germany.
Ulrike ScheibInstitute of Biology, Faculty of Life Sciences, Humboldt University, Berlin, Germany.
Matthias NollInstitute of Biology, Faculty of Life Sciences, Humboldt University, Berlin, Germany.
Nishith GuptaInstitute of Biology, Faculty of Life Sciences, Humboldt University, Berlin, Germany Gupta.Nishith@hu-berlin.de.ORCID 0000-0003-1452-5126
Humboldt-Universität zu Berlin · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

cGMP signaling is one of the master regulators of diverse functions in eukaryotes; however, its architecture and functioning in protozoans remain poorly understood. Herein, we report an exclusive guanylate cyclase coupled with N-terminal P4-ATPase in a common parasitic protist,

Indexed as

Protein Interaction Domains and MotifsAdenosine TriphosphatasesAmino Acid SequenceGuanylate CyclaseProtein BindingProtein MultimerizationProtozoan ProteinsStructure-Activity RelationshipToxoplasmaAdenosine TriphosphatasesGuanylate CyclaseProtozoan Proteins

Identifiers

PMID31235476
PMCPMC6592433
OpenAlexW2952346036

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.