Evidence map›Paper›PMID 31235345›Full record

ArticleAlcohol (Fayetteville, N.Y.)2019

Alcohol potentiates RSV-mediated injury to ciliated airway epithelium.

Todd A Wyatt, Kristina L Bailey, Samantha M Simet, Kristi J Warren, Jenea M Sweeter, Jane M DeVasure, Jaqueline A Pavlik, Joseph H Sisson

Open access · greenAbstract read
In one paragraph

Article in Alcohol (Fayetteville, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
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  8. Review
  9. Motile cilia genetics and cell biology: big results from little mice.Cellular and molecular life sciences : CMLS · 2021
    Review
  10. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Todd A WyattUniversity of Nebraska Medical Center, Pulmonary, Critical Care, Sleep & Allergy, 985910 Nebraska Medical Center, Omaha, NE, 68198-5910, United States; Veterans Affairs Nebraska-Western Iowa Health Care System, Omaha, NE, 68105, United States; University of Nebraska Medical Center, Department of Environmental, Agricultural, & Occupational Health, Omaha, NE, 68198-5910, United States. Electronic address: twyatt@unmc.edu.
Kristina L BaileyUniversity of Nebraska Medical Center, Pulmonary, Critical Care, Sleep & Allergy, 985910 Nebraska Medical Center, Omaha, NE, 68198-5910, United States; Veterans Affairs Nebraska-Western Iowa Health Care System, Omaha, NE, 68105, United States.
Samantha M SimetUniversity of Nebraska Medical Center, Department of Genetics, Cell Biology & Anatomy, Omaha, NE, 68198-6395, United States.
Kristi J WarrenUniversity of Nebraska Medical Center, Pulmonary, Critical Care, Sleep & Allergy, 985910 Nebraska Medical Center, Omaha, NE, 68198-5910, United States.
Jenea M SweeterUniversity of Nebraska Medical Center, Pulmonary, Critical Care, Sleep & Allergy, 985910 Nebraska Medical Center, Omaha, NE, 68198-5910, United States.
Jane M DeVasureUniversity of Nebraska Medical Center, Pulmonary, Critical Care, Sleep & Allergy, 985910 Nebraska Medical Center, Omaha, NE, 68198-5910, United States.
Jaqueline A PavlikUniversity of Nebraska Medical Center, Pulmonary, Critical Care, Sleep & Allergy, 985910 Nebraska Medical Center, Omaha, NE, 68198-5910, United States.
Joseph H SissonUniversity of Nebraska Medical Center, Pulmonary, Critical Care, Sleep & Allergy, 985910 Nebraska Medical Center, Omaha, NE, 68198-5910, United States.
University of Nebraska Medical Center · USVA Nebraska Western Iowa Health Care System · US

Funding

ETHANOL MEDIATED CILIA MOTILITY DYSFUNCTIONR01AA008769 · NIAAA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI SISSON, JOSEPH H · 1996 to 2016
$4.4M
Ethanol-mediated cilia motility dysfunctionR37AA008769 · NIAAA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI SISSON, JOSEPH H · 2006 to 2010
$2.4M
Mucociliary clearance in agingR01AG053553 · NIA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BAILEY, KRISTINA L · 2016 to 2020
$1.5M
Alcohol increases tight junction permeability & disrupts translocation of ZO-1F32AA019859 · NIAAA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI SIMET, SAMANTHA · 2011 to 2012
$105k
Malondialdehyde-acetaldehyde adducts and lung injuryI01BX003635 · VA · OMAHA VA MEDICAL CENTER · PI TED RICHARD MIKULS · 2017 to 2026
–
BLR&D Research Career Scientist AwardIK6BX003781 · VA · OMAHA VA MEDICAL CENTER · PI WYATT, TODD A · 2017 to 2021
–
Alcohol consumption and RSV infection in airway injuryI01BX000728 · VA · OMAHA VA MEDICAL CENTER · PI WYATT, TODD A · 2012 to 2015
–
ACETALDEHYDE-MEDIATED BRONCHIAL CILIA DYSFUNCTIONR29AA008769 · NIAAA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI SISSON, JOSEPH H · 1991 to 1995
–
BLRD VA I01 BX000728BLRD VA I01 BX003635BLRD VA IK6 BX003781NIAAA NIH HHS F32 AA019859NIAAA NIH HHS R01 AA008769NIAAA NIH HHS R29 AA008769NIAAA NIH HHS R37 AA008769NIA NIH HHS R01 AG053553
6 · The paper itself

Abstract

Alcohol impairs resolution of respiratory viral infections. Numerous immune response pathways are altered in response to alcohol misuse, including alcohol-induced ciliary dysfunction in the lung. We hypothesized that mucociliary clearance-mediated innate immunity to respiratory syncytial virus (RSV) would be compromised by alcohol exposure. Cilia were assayed using Sisson-Ammons Video Analysis by quantitating the average number of motile points in multiple whole field measurements of mouse tracheal epithelial cells grown on an air-liquid interface. Pretreatment with ethanol alone (100 mM for 24 hours) had no effect on the number of motile cilia. A single dose (TCID

Indexed as

AnimalsCiliaEthanolFemaleMiceMice, Inbred C57BLMucociliary ClearanceRespiratory MucosaRespiratory Syncytial Virus InfectionsEthanolCiliary beat frequencyMouse tracheal epithelial cellProtein kinase CRespiratory syncytial virus

Identifiers

PMID31235345
PMCPMC7100607
OpenAlexW2884799911

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.