Evidence map›Paper›PMID 31235205›Full record

ArticleUltrasound in medicine & biology2019

Parametric Study of Acoustic Droplet Vaporization Thresholds and Payload Release From Acoustically-Responsive Scaffolds.

Xiaofang Lu, Xiaoxiao Dong, Sam Natla, Oliver D Kripfgans, J Brian Fowlkes, Xueding Wang, Renny Franceschi, Andrew J Putnam, Mario L Fabiilli

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ultrasound in medicine & biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
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  5. Acoustically responsive scaffolds: Unraveling release kinetics and mechanisms for sustained, steady drug delivery.Journal of controlled release : official journal of the Controlled Release Society · 2024
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  7. Review
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  12. Extracellular vesicles: Targeting the heart.Frontiers in cardiovascular medicine · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Xiaofang LuDepartment of Radiology, University of Michigan Health System, Ann Arbor, USA.
Xiaoxiao DongDepartment of Radiology, University of Michigan Health System, Ann Arbor, USA; Department of Ultrasound, Army Medical University, Chongqing, China.
Sam NatlaDepartment of Radiology, University of Michigan Health System, Ann Arbor, USA.
Oliver D KripfgansDepartment of Radiology, University of Michigan Health System, Ann Arbor, USA; Applied Physics Program, University of Michigan, Ann Arbor, USA; Department of Biomedical Engineering, University of Michigan, Ann Arbor, USA.
J Brian FowlkesDepartment of Radiology, University of Michigan Health System, Ann Arbor, USA; Applied Physics Program, University of Michigan, Ann Arbor, USA; Department of Biomedical Engineering, University of Michigan, Ann Arbor, USA.
Xueding WangDepartment of Radiology, University of Michigan Health System, Ann Arbor, USA; Department of Biomedical Engineering, University of Michigan, Ann Arbor, USA.
Renny FranceschiDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, USA; Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, USA; Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, USA.
Andrew J PutnamDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, USA.
Mario L FabiilliDepartment of Radiology, University of Michigan Health System, Ann Arbor, USA; Applied Physics Program, University of Michigan, Ann Arbor, USA; Department of Biomedical Engineering, University of Michigan, Ann Arbor, USA. Electronic address: mfabiill@umich.edu.
University of Michigan–Ann Arbor · USMichigan Medicine · US

Funding

Structure, Composition, & Histology Core - Core BP30AR069620 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KARL J JEPSEN · 2016 to 2026
$8.4M
Angiogenic growth factor delivery for vascular regeneration in critical limb ischemia using acoustically-responsive scaffoldsR01HL139656 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mario Leonardo Fabiilli · 2018 to 2026
$5.7M
NHLBI NIH HHS R01 HL139656NIAMS NIH HHS P30 AR069620
6 · The paper itself

Abstract

Hydrogels are commonly used for the delivery of bioactive molecules, especially growth factors and cytokines capable of stimulating tissue regeneration. Regenerative processes are regulated by the concentrations and spatiotemporal presentations of these molecules. With conventional hydrogels, these critical delivery parameters cannot be actively modulated after implantation. We have developed composite hydrogel scaffolds where payload release is non-invasively modulated, in an on-demand manner, using ultrasound (US). These acoustically-responsive scaffolds (ARSs) consist of a fibrin matrix doped with a payload-carrying, perfluorocarbon (PFC) double emulsion. Previously, acoustic droplet vaporization (ADV) was used to trigger release of a pro-angiogenic growth factor, encapsulated in the ARS, which stimulated blood vessel formation in vivo. In the present study, we assess how characteristics of the monodispersed emulsion, fibrin matrix, and US impact ADV thresholds and the release efficiency of a dextran payload. ADV thresholds increased with the molecular weight of the PFC in the emulsion and inversely with the volume fraction of emulsion in the ARS. Payload release from ARSs with perfluoroheptane (C7) or perfluorooctane (C8) emulsions was dependent on the number of z-planes of US used to generate ADV and inversely dependent on the lateral spacing. Conversely, release from ARSs with perfluoropentane (C5) or perfluorohexane (C6) emulsions was less dependent on these US exposure parameters. After ADV, payload diffusion decreased significantly in ARSs with C5 or C6 emulsions compared with ARSs with C7 or C8 emulsions. The expansion of the ARS after ADV decreased with the molecular weight of the PFC. Non-selective release increased with the molecular weight of the PFC and thrombin concentration. Overall, these findings can be used for optimization of ARS properties and US parameters in future therapeutic applications.

Indexed as

AcousticsVolatilizationDextransEmulsionsFibrinFluorocarbonsHeptanesHydrocarbons, FluorinatedHydrogelsPentanesDextransEmulsionsFibrinFluorocarbonsHeptanesHydrocarbons, FluorinatedHydrogelsPentanesperflexaneperfluoroheptaneperfluorooctaneperfluoropentaneAcoustic droplet vaporizationControlled releaseFibrinPerfluorocarbonUltrasound

Identifiers

PMID31235205
PMCPMC6689245
OpenAlexW2950184818

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.