Evidence map›Paper›PMID 31235099›Full record

ArticleDiabetes & metabolic syndrome

High prevalence of insulin resistance and occurrence prior to hyperinsulinemia threshold among people living with HIV in Pune, India.

Ivan Marbaniang, Shashikala Sangle, Sonali Salvi, Vandana Kulkarni, Dhananjay Shere, Prasad Deshpande, Smita Nimkar, Amita Gupta, Vidya Mave

Open access · greenAbstract read
In one paragraph

Article in Diabetes & metabolic syndrome. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Ivan MarbaniangByramjee Jeejeebhoy Government Medical College - Johns Hopkins University Clinical Research Site, Pune, India. Electronic address: ivanmarb@gmail.com.
Shashikala SangleByramjee Jeejeebhoy Government Medical College and Sassoon General Hospitals, Pune, India.
Sonali SalviByramjee Jeejeebhoy Government Medical College and Sassoon General Hospitals, Pune, India.
Vandana KulkarniByramjee Jeejeebhoy Government Medical College - Johns Hopkins University Clinical Research Site, Pune, India.
Dhananjay ShereByramjee Jeejeebhoy Government Medical College - Johns Hopkins University Clinical Research Site, Pune, India.
Prasad DeshpandeByramjee Jeejeebhoy Government Medical College - Johns Hopkins University Clinical Research Site, Pune, India.
Smita NimkarByramjee Jeejeebhoy Government Medical College - Johns Hopkins University Clinical Research Site, Pune, India.
Amita GuptaJohns Hopkins School of Medicine, Baltimore, USA.
Vidya MaveByramjee Jeejeebhoy Government Medical College - Johns Hopkins University Clinical Research Site, Pune, India; Johns Hopkins School of Medicine, Baltimore, USA.
Johns Hopkins University · USB. J. Medical College & Sassoon Hospital · INGovernment Medical College · INJohns Hopkins Medicine · US

Funding

The Asia-Pacific HIV Research CollaborationU01AI069907 · NIAID · FOUNDATION FOR AIDS RESEARCH · PI ANNETTE H SOHN · 2006 to 2026
$44.8M
The Johns Hopkins Baltimore-Washington-India Clinical Trials Unit (BWI CTU)UM1AI069465 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Charles W. Flexner, Amita Gupta · 2012 to 2026
$34.1M
NIAID NIH HHS U01 AI069907NIAID NIH HHS UM1 AI069465
6 · The paper itself

Abstract

backgroundDiabetes prevalence in HIV is not well characterized for India, despite the high burden of both individual diseases. Epidemiology of insulin resistance (IR): a precursor to diabetes, and its associated risk factors are also poorly understood in Asian Indian people living with HIV (PLHIV). We assessed the prevalence of diabetes and IR in Pune, India and the associated risk factors for IR.

methodsCross-sectional analysis of adult (≥18 years) PLHIV receiving care at Byramjee Jeejeebhoy Government Medical College and Sassoon General Hospitals, Pune, India (BJGMC- SGH). Proportions and medians of PLHIV characteristics by diabetes status and IR were described. Homeostatic Model Assessment (HOMA) index value ≥2 was used to define IR. Line of least squares assessed the relationship between IR and hyperinsulinemia. Association between sociodemographic, clinical factors with IR was determined using logistic regression.

resultsOf 485 enrollees, 47% were men, median age was 40 years (IQR: 35-46), median CD4 counts were 389 cells/mm

conclusionsOne fourth of the study population was diabetic or prediabetic and more than a third had IR. Better understanding of diabetes disease progression in relation to IR and the effect of physical activity on central obesity among Asian Indian PLHIV is mandated.

Indexed as

Insulin ResistanceAdultBiomarkersBlood GlucoseCross-Sectional StudiesDiabetes MellitusFemaleFollow-Up StudiesGlycated HemoglobinHIVHIV InfectionsHumansHyperinsulinismIndiaMaleMiddle AgedBiomarkersBlood GlucoseGlycated Hemoglobinhemoglobin A1c protein, human

Identifiers

PMID31235099
PMCPMC6597186
OpenAlexW2937559195

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.