Evidence map›Paper›PMID 31234834›Full record

ArticleBMC veterinary research2019

Additive Bayesian networks for antimicrobial resistance and potential risk factors in non-typhoidal Salmonella isolates from layer hens in Uganda.

Sonja Hartnack, Terence Odoch, Gilles Kratzer, Reinhard Furrer, Yngvild Wasteson, Trine M L'Abée-Lund, Eystein Skjerve

Open access · goldAbstract read
In one paragraph

Article in BMC veterinary research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Sonja HartnackSection of Epidemiology, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 270, 8057, Zurich, Switzerland. Sonja.Hartnack@access.uzh.ch.ORCID http://orcid.org/0000-0002-5757-5708
Terence OdochDepartment of Biosecurity, Ecosystems and Veterinary Public Health, College of Veterinary Medicine, Animal Resources and Biosecurity (COVAB), Makerere University, P.O. Box 7062, Kampala, Uganda.
Gilles KratzerDepartment of Mathematics, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.
Reinhard FurrerDepartment of Mathematics, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.
Yngvild WastesonDepartment of Food Safety and Infection Biology, Faculty of Veterinary Medicine, Norwegian University of Life Sciences (NMBU), 0454, Oslo, Norway.
Trine M L'Abée-LundDepartment of Food Safety and Infection Biology, Faculty of Veterinary Medicine, Norwegian University of Life Sciences (NMBU), 0454, Oslo, Norway.
Eystein SkjerveDepartment of Food Safety and Infection Biology, Faculty of Veterinary Medicine, Norwegian University of Life Sciences (NMBU), 0454, Oslo, Norway.
Norwegian University of Life Sciences · NOUniversity of Zurich · CHMakerere University · UGZHAW Zurich University of Applied Sciences · CH

Funding

NORHED UGA-13/0031
6 · The paper itself

Abstract

backgroundMulti-drug resistant bacteria are seen increasingly and there are gaps in our understanding of the complexity of antimicrobial resistance, partially due to a lack of appropriate statistical tools. This hampers efficient treatment, precludes determining appropriate intervention points and renders prevention very difficult.

methodsWe re-analysed data from a previous study using additive Bayesian networks. The data contained information on resistances against seven antimicrobials and seven potential risk factors from 86 non-typhoidal Salmonella isolates from laying hens in 46 farms in Uganda.

resultsThe final graph contained 22 links between risk factors and antimicrobial resistances. Solely ampicillin resistance was linked to the vaccinating person and disposal of dead birds. Systematic associations between ampicillin and sulfamethoxazole/trimethoprim and chloramphenicol, which was also linked to sulfamethoxazole/trimethoprim were detected. Sulfamethoxazole/trimethoprim was also directly linked to ciprofloxacin and trimethoprim. Trimethoprim was linked to sulfonamide and ciprofloxacin, which was also linked to sulfonamide. Tetracycline was solely linked to ciprofloxacin.

conclusionsAlthough the results needs to be interpreted with caution due to a small data set, additive Bayesian network analysis allowed a description of a number of associations between the risk factors and antimicrobial resistances investigated.

Indexed as

Drug Resistance, Multiple, BacterialAnimalsAnti-Bacterial AgentsBayes TheoremFemalePoultry DiseasesRisk FactorsSalmonellaSalmonella Infections, AnimalUgandaAnti-Bacterial AgentsAntimicrobial resistanceMulti-drug resistancePatterns of antimicrobial resistanceSalmonella

Identifiers

PMID31234834
PMCPMC6591809
OpenAlexW2950896249

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.