ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2020
Impact of stroke co-morbidities on cortical collateral flow following ischaemic stroke.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 40 citations in OpenAlex.
- Association between stress hyperglycemia and outcomes in patients with acute ischemic stroke due to large vessel occlusion.CNS neuroscience & therapeutics · 2023Trial
- The Association Between Stress Hyperglycemia Ratio and Short-Term Outcomes After Successful Recanalization by Mechanical Thrombectomy in Acute Ischemic Stroke Patients.Brain and behavior · 2025Article
- Shear Stress Targeted Delivery of Nitroglycerin to Brain Collaterals Improves Ischaemic Stroke Outcome.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- History of pre-eclampsia negatively impacts stroke severity postpartum in rats.Neuroprotection (Chichester, England) · 2025Article
- Impact of stress hyperglycemia mediating tissue-level collaterals on futile recanalization in large vessel occlusion patients.Frontiers in endocrinology · 2025Article
- Article
- Melanocortin Derivatives Induced Vascularization and Neuroglial Proliferation in the Rat Brain under Conditions of Cerebral Ischemia.Current issues in molecular biology · 2024Article
- Observational
- Promising Cerebral Blood Flow Enhancers in Acute Ischemic Stroke.Translational stroke research · 2023Review
- Leptomeningeal Collaterals and Infarct Progression in Patients With Acute Large-Vessel Occlusion and Low NIHSS.Stroke (Hoboken, N.J.) · 2023Article
- Therapeutic Induction of Collateral Flow.Translational stroke research · 2023Review
- An Enriched Environment Promotes Motor Function through Neuroprotection after Cerebral Ischemia.BioMed research international · 2023Article
- Laser speckle contrast imaging for blood flow monitoring in predicting outcomes after cerebral ischemia-reperfusion injury in mice.BMC neuroscience · 2022Article
- Optimizing intraluminal monofilament model of ischemic stroke in middle-aged Sprague-Dawley rats.BMC neuroscience · 2022Article
- Collateral Supply in Preclinical Cerebral Stroke Models.Translational stroke research · 2022Review
- Role of diabetes in collateral status assessed in CT perfusion-derived dynamic CTA in anterior circulation stroke.Neuroradiology · 2022Article
- Intermittent hypoxia conditioning as a potential prevention and treatment strategy for ischemic stroke: Current evidence and future directions.Frontiers in neuroscience · 2022Review
- Pre-Existing Non-Disabling Encephalomalacia Confers Risk to Stroke Outcomes After Endovascular Treatment.Frontiers in neurology · 2022Article
- Hemodynamics of Leptomeningeal Collaterals after Large Vessel Occlusion and Blood Pressure Management with Endovascular Treatment.Journal of stroke · 2021Review
- Time Course and Clinical Relevance of Neurological Deterioration After Endovascular Recanalization Therapy for Anterior Circulation Large Vessel Occlusion Stroke.Frontiers in aging neuroscience · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute hyperglycaemia and chronic hypertension worsen stroke outcome but their impact on collateral perfusion, a determinant of penumbral life span, is poorly understood. Laser-speckle contrast imaging (LSCI) was used to determine the influence of these stroke comorbidities on cortical perfusion after permanent middle cerebral artery occlusion (pMCAO) in spontaneously hypertensive stroke prone rats (SHRSP) and normotensive Wistar rats. Four independent studies were conducted. In animals without pMCAO, cortical perfusion remained stable over 180 min. Following pMCAO, cortical perfusion was markedly reduced at 30 min then gradually increased, via cortical collaterals, over the subsequent 3.5 h. In the contralateral non-ischaemic hemisphere, perfusion did not change over time. Acute hyperglycaemia (in normotensive Wistar) and chronic hypertension (SHRSP) attenuated the restoration of cortical perfusion after pMCAO. Inhaled nitric oxide did not influence cortical perfusion in SHRSP following pMCAO. Thus, hyperglycaemia at the time of arterial occlusion or pre-existing hypertension impaired the dynamic recruitment of cortical collaterals after pMCAO. The impairment of collateral recruitment may contribute to the detrimental effects these comorbidities have on stroke outcome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.