Evidence map›Paper›PMID 31234555›Full record

ReviewInternational journal of molecular sciences2019

Anti-Inflammatory Activities of Marine Algae in Neurodegenerative Diseases.

Maria Cristina Barbalace, Marco Malaguti, Laura Giusti, Antonio Lucacchini, Silvana Hrelia, Cristina Angeloni

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
19.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 147 citations in OpenAlex.

  1. Effects ofInternational journal of environmental research and public health · 2020
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7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Maria Cristina BarbalaceDepartment for Life Quality Studies, Alma Mater Studiorum-University of Bologna, 40126 Bologna, Italy. maria.barbalace2@unibo.it.
Marco MalagutiDepartment for Life Quality Studies, Alma Mater Studiorum-University of Bologna, 40126 Bologna, Italy. marco.malaguti@unibo.it.ORCID 0000-0003-0349-7772
Laura GiustiSchool of Pharmacy, University of Camerino, 62032 Camerino, Italy. laura.giusti@unicam.it.ORCID 0000-0001-7366-1932
Antonio LucacchiniDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa 56126, Italy. antonio.lucacchini@gmail.com.ORCID 0000-0002-0917-4491
Silvana HreliaDepartment for Life Quality Studies, Alma Mater Studiorum-University of Bologna, 40126 Bologna, Italy. silvana.hrelia@unibo.it.ORCID 0000-0001-7857-4512
Cristina AngeloniSchool of Pharmacy, University of Camerino, 62032 Camerino, Italy. cristina.angeloni@unicam.it.ORCID 0000-0002-6731-6187
University of Bologna · ITUniversità di Camerino · ITUniversity of Pisa · IT

Funding

Ministero dell'Istruzione, dell'Università e della Ricerca MIUR-PRIN 2015 (N. 20152HKF3Z)
6 · The paper itself

Abstract

Neuroinflammation is one of the main contributors to the onset and progression of neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. Microglial and astrocyte activation is a brain defense mechanism to counteract harmful pathogens and damaged tissues, while their prolonged activation induces neuroinflammation that can trigger or exacerbate neurodegeneration. Unfortunately, to date there are no pharmacological therapies able to slow down or stop the progression of neurodegeneration. For this reason, research is turning to the identification of natural compounds with protective action against these diseases. Considering the important role of neuroinflammation in the onset and development of neurodegenerative pathologies, natural compounds with anti-inflammatory activity could be good candidates for developing effective therapeutic strategies. Marine organisms represent a huge source of natural compounds, and among them, algae are appreciated sources of important bioactive components such as antioxidants, proteins, vitamins, minerals, soluble dietary fibers, polyunsaturated fatty acids, polysaccharides, sterols, carotenoids, tocopherols, terpenes, phycobilins, phycocolloids, and phycocyanins. Recently, numerous anti-inflammatory compounds have been isolated from marine algae with potential protective efficacy against neuroinflammation. This review highlights the key inflammatory processes involved in neurodegeneration and the potential of specific compounds from marine algae to counteract neuroinflammation in the CNS.

Indexed as

Alzheimer DiseaseAnimalsAnti-Inflammatory AgentsAntioxidantsBrainCarotenoidsHumansInflammationNeurodegenerative DiseasesParkinson DiseasePhytochemicalsSeaweedSterolsTerpenesAnti-Inflammatory AgentsAntioxidantsCarotenoidsPhytochemicalsSterolsTerpenesalgaeneurodegenerationneurodegenerative diseasesneuroinflammationseaweeds

Identifiers

PMID31234555
PMCPMC6628294
OpenAlexW2949691357

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.