Evidence map›Paper›PMID 31234551›Full record

ArticleInternational journal of molecular sciences2019

New Lectins from Mediterranean Flora. Activity against HT29 Colon Cancer Cells.

Isabel Oliveira, António Nunes, Ana Lima, Pedro Borralho, Cecília Rodrigues, Ricardo Boavida Ferreira, Ana Cristina Ribeiro

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

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    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Isabel OliveiraDepartment of Toxicological and Bromatological Sciences (DCTB), Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisboa, Portugal. ioliveira2@campus.ul.pt.
António NunesDepartment of Toxicological and Bromatological Sciences (DCTB), Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisboa, Portugal. filipe_estesl@yahoo.com.
Ana LimaLinking Landscape, Environment, Agriculture and Food (LEAF), Higher Institute of Agronomy, Universidade de Lisboa, 1349-017y Lisboa, Portugal. agusmaolima@gmail.com.
Pedro BorralhoResearch Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisboa, Portugal. borralhopm@gmail.com.
Cecília RodriguesResearch Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisboa, Portugal. cmprodrigues@ff.ulisboa.pt.
Ricardo Boavida FerreiraLinking Landscape, Environment, Agriculture and Food (LEAF), Higher Institute of Agronomy, Universidade de Lisboa, 1349-017y Lisboa, Portugal. rbferreira@isa.ulisboa.pt.
Ana Cristina RibeiroDepartment of Toxicological and Bromatological Sciences (DCTB), Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisboa, Portugal. acribeiro@ff.ulisboa.pt.ORCID 0000-0001-9555-5735
University of Lisbon · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Experiments conducted in vitro and in vivo, as well as some preclinical trials for cancer therapeutics, support the antineoplastic properties of lectins. A screening of antitumoral activity on HT29 colon cancer cells, based on polypeptide characterization and specific lectin binding to HT29 cells membrane receptors, was performed in order to assess the bioactivities present in four Mediterranean plant species:

Indexed as

Antineoplastic AgentsCell SurvivalColonic NeoplasmsEricaceaeHT29 CellsHumansJuniperusPlant ExtractsPlant LeavesPlant LectinsAntineoplastic AgentsPlant ExtractsPlant Lectinsantitumor activityglycosylated receptorsHT29 colon cancer cellslectins

Identifiers

PMID31234551
PMCPMC6627736
OpenAlexW2951227962

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.