Evidence map›Paper›PMID 31234485›Full record

ArticlePathogens (Basel, Switzerland)2019

Experimental Infection of Human Volunteers with the Heat-Stable Enterotoxin-Producing Enterotoxigenic

Sunniva Todnem Sakkestad, Hans Steinsland, Steinar Skrede, Elisabeth Kleppa, Kristine Lillebø, Marianne Sævik, Hanne Søyland, Astrid Rykkje Heien, Marit Gjerde Tellevik, Eileen M Barry and 2 more

Open access · goldAbstract read
In one paragraph

Article in Pathogens (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Recent progress in enterotoxigenicInfection and immunity · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Sunniva Todnem SakkestadDepartment of Clinical Science, Faculty of Medicine, University of Bergen, Postbox 7804, 5020 Bergen, Norway. sunniva.sakkestad@gmail.com.
Hans SteinslandCentre for International Health, Department of Global Public Health and Primary Care, Faculty of Medicine, University of Bergen, Postbox 7894, 5020 Bergen, Norway. hans.steinsland@uib.no.
Steinar SkredeDepartment of Clinical Science, Faculty of Medicine, University of Bergen, Postbox 7804, 5020 Bergen, Norway. steinar.skrede@helse-bergen-no.
Elisabeth KleppaDepartment of Microbiology, Haukeland University Hospital, 5021 Bergen, Norway. elisabethkleppa@gmail.com.
Kristine LillebøDivision for Infectious Diseases, Department of Medicine, Haukeland University Hospital, 5021 Bergen, Norway. kristine.lillebo@helse-bergen.no.
Marianne SævikDivision for Infectious Diseases, Department of Medicine, Haukeland University Hospital, 5021 Bergen, Norway. marianne.saevik@helse-bergen.no.
Hanne SøylandDivision for Infectious Diseases, Department of Medicine, Haukeland University Hospital, 5021 Bergen, Norway. hanne.soyland@helse-bergen.no.
Astrid Rykkje HeienDivision for Infectious Diseases, Department of Medicine, Haukeland University Hospital, 5021 Bergen, Norway. arheien@hotmail.com.ORCID 0000-0003-1546-9613
Marit Gjerde TellevikNorwegian National Advisory Unit on Tropical Infectious Diseases, Department of Medicine, Haukeland University Hospital, 5021 Bergen, Norway. marit.gjerde.tellevik@helse-bergen.no.
Eileen M BarryCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD 21201, USA. embarry@medicine.umaryland.edu.
Halvor SommerfeltCentre for Intervention Science in Material and Child Health (CISMAC), Department of Global Public Health and Primary Care, Faculty of Medicine, University of Bergen, Postbox 7804, 5020 Bergen, Norway. Halvor.Sommerfelt@uib.no.
Kurt HanevikDepartment of Clinical Science, Faculty of Medicine, University of Bergen, Postbox 7804, 5020 Bergen, Norway. Kurt.Hanevik@uib.no.
Haukeland University Hospital · NOUniversity of Bergen · NONorwegian Institute of Public Health · NOUniversity of Maryland, Baltimore · US

Funding

Enteric Vaccine Initiative "Developing a safe STh-based vaccine for protection against ETEC diarrhoea"European Union's Seventh Framework Programme for research, technological development and demonstration 261472-STOPENTERICSNorges Forskningsråd 234364
6 · The paper itself

Abstract

Infection with enterotoxigenic

Indexed as

Colonization Factor Antigen Icontrolled human challenge modeldiarrhoeaenterotoxigenic Escherichia coliexperimental infectionheat-stable enterotoxinYghJ

Identifiers

PMID31234485
PMCPMC6630672
OpenAlexW2951268986

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.