Evidence map›Paper›PMID 31234417›Full record

ArticleJournal of clinical medicine2019

Interrogation of Phenotypic Plasticity between Epithelial and Mesenchymal States in Breast Cancer.

Sugandha Bhatia, James Monkman, Tony Blick, Cletus Pinto, Mark Waltham, Shivashankar H Nagaraj, Erik W Thompson

Abstract read
In one paragraph

Article in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sugandha BhatiaInstitute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD 4059, Australia. sugandha.bhatia@hdr.qut.edu.au.
James MonkmanInstitute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD 4059, Australia. james.monkman@qut.edu.au.
Tony BlickInstitute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD 4059, Australia. blick_tony@yahoo.com.au.
Cletus PintoInvasion and Metastasis Unit, St. Vincent's Institute, Melbourne, VIC 3065, Australia. cletusp136@gmail.com.
Mark WalthamInvasion and Metastasis Unit, St. Vincent's Institute, Melbourne, VIC 3065, Australia. mwaltham@unimelb.edu.au.
Shivashankar H NagarajInstitute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD 4059, Australia. shiv.nagaraj@qut.edu.au.
Erik W ThompsonInstitute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD 4059, Australia. e2.thompson@qut.edu.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dynamic interconversions between transitional epithelial and mesenchymal states underpin the epithelial mesenchymal plasticity (EMP) seen in some carcinoma cell systems. We have delineated epithelial and mesenchymal subpopulations existing within the PMC42-LA breast cancer cell line by their EpCAM expression. These purified but phenotypically plastic states, EpCAM

Indexed as

copy number variations (CNV)epithelial-mesenchymal transition (EMT)intratumoral heterogeneitymesenchymal-epithelial transition (MET)phenotypic plasticitysingle cell-derived cloneswhole exome sequencing

Identifiers

PMID31234417
PMCPMC6617164

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.