Evidence map›Paper›PMID 31234412›Full record

ArticleToxins2019

Chemical Synthesis, Proper Folding, Na

Sébastien Nicolas, Claude Zoukimian, Frank Bosmans, Jérôme Montnach, Sylvie Diochot, Eva Cuypers, Stephan De Waard, Rémy Béroud, Dietrich Mebs, David Craik and 4 more

Open access · goldAbstract read
In one paragraph

Article in Toxins, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Review
  3. Modulation of human dorsal root ganglion neuron firing by the Nav1.8 inhibitor suzetrigine.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. The venom ofFrontiers in pharmacology · 2025
    Article
  5. Review
  6. Article
  7. Non-Opioid Peptides Targeting Opioid Effects.International journal of molecular sciences · 2021
    Review
  8. Pain-related toxins in scorpion and spider venoms: a face to face with ion channels.The journal of venomous animals and toxins including tropical diseases · 2021
    Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 4 countries.

Sébastien NicolasInstitut du Thorax, Inserm UMR 1087/CNRS UMR 6291, LabEx "Ion Channels, Science & Therapeutics", F-44007 Nantes, France. sebastien.nicolas@univ-nantes.fr.
Claude ZoukimianSmartox Biotechnology, 6 rue des Platanes, F-38120 Saint-Egrève, France. Claude.Zoukimian@univ-grenoble-alpes.fr.
Frank BosmansFaculty of Medicine and Health Sciences, Department of Basic and Applied Medical Sciences, 9000 Gent, Belgium. frank.bosmans@ugent.be.
Jérôme MontnachInstitut du Thorax, Inserm UMR 1087/CNRS UMR 6291, LabEx "Ion Channels, Science & Therapeutics", F-44007 Nantes, France. jerome.montnach@univ-nantes.fr.
Sylvie DiochotUniversité Côte d'Azur, CNRS UMR7275, Institut de Pharmacologie Moléculaire et Cellulaire, 660 route des lucioles, 6560 Valbonne, France. diochot@ipmc.cnrs.fr.
Eva CuypersToxicology and Pharmacology, University of Leuven, Campus Gasthuisberg, P.O. Box 922, Herestraat 49, 3000 Leuven, Belgium. eva.cuypers@kuleuven.be.
Stephan De WaardInstitut du Thorax, Inserm UMR 1087/CNRS UMR 6291, LabEx "Ion Channels, Science & Therapeutics", F-44007 Nantes, France. stephan.de-waard@etu.univ-nantes.fr.
Rémy BéroudSmartox Biotechnology, 6 rue des Platanes, F-38120 Saint-Egrève, France. remy.beroud@smartox-biotech.com.
Dietrich MebsInstitute of Legal Medicine, University of Frankfurt, Kennedyallee 104, Frankfurt, Germany. mebs@em.uni-frankfurt.de.
David CraikInstitute for Molecular Bioscience, University of Queensland, Brisbane 4072, Australia. d.craik@imb.uq.edu.au.
Didier BoturynDepartment of Molecular Chemistry, Univ. Grenoble Alpes, CNRS, 570 rue de la chimie, CS 40700, 38000 Grenoble, France. lazdunski@ipmc.cnrs.fr.
Michel LazdunskiUniversité Côte d'Azur, CNRS UMR7275, Institut de Pharmacologie Moléculaire et Cellulaire, 660 route des lucioles, 6560 Valbonne, France. lazdunski@ipmc.cnrs.fr.
Jan TytgatToxicology and Pharmacology, University of Leuven, Campus Gasthuisberg, P.O. Box 922, Herestraat 49, 3000 Leuven, Belgium. jan.tytgat@kuleuven.be.
Michel De WaardInstitut du Thorax, Inserm UMR 1087/CNRS UMR 6291, LabEx "Ion Channels, Science & Therapeutics", F-44007 Nantes, France. michel.dewaard@univ-nantes.fr.
Centre National de la Recherche Scientifique · FRKU Leuven · BEGoethe University Frankfurt · DEThe University of Queensland · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phlotoxin-1 (PhlTx1) is a peptide previously identified in tarantula venom (

Indexed as

Amino Acid SequenceAnalgesicsAnimalsCHO CellsCricetulusFemaleFormaldehydeMice, Inbred C57BLNAV1.7 Voltage-Gated Sodium ChannelOocytesPainPeptidesProtein FoldingSpidersSpider VenomsVoltage-Gated Sodium Channel BlockersAnalgesicsFormaldehydeNAV1.7 Voltage-Gated Sodium ChannelPeptidesSCN9A protein, humanSpider VenomsVoltage-Gated Sodium Channel Blockersautomated patch-clampdirected disulfide bond formationNav1.7Nav channel activitypain targetspider toxin

Identifiers

PMID31234412
PMCPMC6628435
OpenAlexW2951262611

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.