Evidence map›Paper›PMID 31234364›Full record

ArticlePharmaceuticals (Basel, Switzerland)2019

Design and Synthesis of CNS-targeted Flavones and Analogues with Neuroprotective Potential Against H

Ana M de Matos, Alice Martins, Teresa Man, David Evans, Magnus Walter, Maria Conceição Oliveira, Óscar López, José G Fernandez-Bolaños, Philipp Dätwyler, Beat Ernst and 4 more

Abstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Evaluation of the In Vitro Blood-Brain Barrier Transport ofInternational journal of molecular sciences · 2025
    Article
  2. Article
  3. Journal of microbiology and biotechnology · 2023
    Article
  4. Article
  5. Synthesis, structural characterization and study of antioxidant and anti-PrPJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2023
    Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ana M de MatosCenter of Chemistry and Biochemistry, Faculdade de Ciências, Universidade de Lisboa, Ed. C8, Campo Grande, 1749-016 Lisboa, Portugal. paula.macedo@nms.unl.pt.
Alice MartinsCenter of Chemistry and Biochemistry, Faculdade de Ciências, Universidade de Lisboa, Ed. C8, Campo Grande, 1749-016 Lisboa, Portugal. aimartins@fc.ul.pt.
Teresa ManDepartment of Chemistry, Erl Wood Manor, Eli Lilly, Windlesham, Surrey GU20 6PH, UK. man_teresa@lilly.com.
David EvansDepartment of Chemistry, Erl Wood Manor, Eli Lilly, Windlesham, Surrey GU20 6PH, UK. evans_david_de@lilly.com.
Magnus WalterAbbvie Germany, Knollstr. 51, 67061 Ludwigshafen, Germany. magnus.walter@abbvie.com.
Maria Conceição OliveiraCentro de Química Estrutural, Instiuto Superior Técnico, Ulisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal. conceicao.oliveira@tecnico.ulisboa.pt.ORCID 0000-0002-3068-4920
Óscar LópezDepartamento de Química Orgánica, Facultad de Química, Universidad de Sevilla, Apartado 1203, E-41071 Sevilla, Spain. osc-lopez@us.es.
José G Fernandez-BolañosDepartamento de Química Orgánica, Facultad de Química, Universidad de Sevilla, Apartado 1203, E-41071 Sevilla, Spain. bolanos@us.es.
Philipp DätwylerDepartment of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, CH-4056 Basel, Switzerland. philipp.daetwyler@roche.com.
Beat ErnstDepartment of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, CH-4056 Basel, Switzerland. beat.ernst@unibas.ch.
M Paula MacedoMEDIR: Metabolic Disorders, CEDOC Chronic Diseases, Nova Medical School, Campus Sant'Ana, Rua Câmara Pestana, 6, Lab 3.8, 1150-082 Lisboa, Portugal. paula.macedo@nms.unl.pt.ORCID 0000-0002-2549-0275
Marialessandra ContinoDipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari/Biofordrug, Via Edoardo Orabona, 4-70125 Bari, Italy. marialessandra.contino@uniba.it.
Nicola A ColabufoDipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari/Biofordrug, Via Edoardo Orabona, 4-70125 Bari, Italy. nicolaantonio.colabufo@uniba.it.
Amélia P RauterCenter of Chemistry and Biochemistry, Faculdade de Ciências, Universidade de Lisboa, Ed. C8, Campo Grande, 1749-016 Lisboa, Portugal. aprauter@fc.ul.pt.ORCID 0000-0003-3790-7952

Funding

Fundação para a Ciência e a Tecnologia SFRH/BD/93170/2013Fundação para a Ciência e a Tecnologia UID/Multi/0612/2019Seventh Framework Programme FP7-PEOPLE-2013-IAPP, GA 612347
6 · The paper itself

Abstract

With the lack of available drugs able to prevent the progression of Alzheimer's disease (AD), the discovery of new neuroprotective treatments able to rescue neurons from cell injury is presently a matter of extreme importance and urgency. Here, we were inspired by the widely reported potential of natural flavonoids to build a library of novel flavones, chromen-4-ones and their

Indexed as

Alzheimer’s diseaseAβ1-42C-glucosyl flavonoidscholinesterase inhibitorschromen-4-onesflavonesPAMPA

Identifiers

PMID31234364
PMCPMC6630837

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.