Evidence map›Paper›PMID 31234363›Full record

ArticleJournal of clinical medicine2019

Fully Automated Support System for Diagnosis of Breast Cancer in Contrast-Enhanced Spectral Mammography Images.

Annarita Fanizzi, Liliana Losurdo, Teresa Maria A Basile, Roberto Bellotti, Ubaldo Bottigli, Pasquale Delogu, Domenico Diacono, Vittorio Didonna, Alfonso Fausto, Angela Lombardi and 4 more

Abstract read
In one paragraph

Article in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Article
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  3. Review
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  6. Machine learning and new insights for breast cancer diagnosis.The Journal of international medical research · 2024
    Review
  7. State-of-the-art for contrast-enhanced mammography.The British journal of radiology · 2024
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Identifying factors that may influence the classification performance of radiomics models using contrast-enhanced mammography (CEM) images.Cancer imaging : the official publication of the International Cancer Imaging Society · 2022
    Article
  16. Article
  17. Article
  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Annarita FanizziDip. di Diagnosi e Terapia per Immagini, I.R.C.C.S. Istituto Tumori "Giovanni Paolo II" di Bari, 70124 Bari, Italy. annarita.fanizzi.af@gmail.com.ORCID 0000-0002-2729-9896
Liliana LosurdoDip. di Diagnosi e Terapia per Immagini, I.R.C.C.S. Istituto Tumori "Giovanni Paolo II" di Bari, 70124 Bari, Italy. lilianalosurdo@gmail.com.ORCID 0000-0002-4964-7951
Teresa Maria A BasileDip. Interateneo di Fisica "M. Merlin", Università degli Studi di Bari "A. Moro", 70125 Bari, Italy. teresamaria.basile@uniba.it.
Roberto BellottiDip. Interateneo di Fisica "M. Merlin", Università degli Studi di Bari "A. Moro", 70125 Bari, Italy. roberto.bellotti@uniba.it.
Ubaldo BottigliDip. di Scienze Fisiche, della Terra e dell'Ambiente, Università degli Studi di Siena, 53100 Siena, Italy. ubaldo.bottigli@unisi.it.
Pasquale DeloguDip. di Scienze Fisiche, della Terra e dell'Ambiente, Università degli Studi di Siena, 53100 Siena, Italy. pasquale.delogu@unisi.it.ORCID 0000-0003-2026-2000
Domenico DiaconoINFN-Istituto Nazionale di Fisica Nucleare, Sezione di Bari, 70125 Bari, Italy. domenico.diacono@ba.infn.it.
Vittorio DidonnaDip. di Diagnosi e Terapia per Immagini, I.R.C.C.S. Istituto Tumori "Giovanni Paolo II" di Bari, 70124 Bari, Italy. v.didonna@oncologico.bari.it.
Alfonso FaustoDip. di Diagnostica per Immagini, Azienda Ospedaliera Universitaria Senese, 53100 Siena, Italy. afausto@sirm.org.
Angela LombardiINFN-Istituto Nazionale di Fisica Nucleare, Sezione di Bari, 70125 Bari, Italy. angela.lombardi@ba.infn.it.
Vito LorussoDip. Area Medica, I.R.C.C.S. Istituto Tumori "Giovanni Paolo II" di Bari, 70124 Bari, Italy. v.lorusso@oncologico.bari.it.
Raffaella MassafraDip. di Diagnosi e Terapia per Immagini, I.R.C.C.S. Istituto Tumori "Giovanni Paolo II" di Bari, 70124 Bari, Italy. massafraraffaella@gmail.com.
Sabina TangaroINFN-Istituto Nazionale di Fisica Nucleare, Sezione di Bari, 70125 Bari, Italy. Sonia.Tangaro@ba.infn.it.ORCID 0000-0002-1372-3916
Daniele La ForgiaDip. di Diagnosi e Terapia per Immagini, I.R.C.C.S. Istituto Tumori "Giovanni Paolo II" di Bari, 70124 Bari, Italy. d.laforgia@oncologico.bari.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Contrast-Enhanced Spectral Mammography (CESM) is a novelty instrumentation for diagnosing of breast cancer, but it can still be considered operator dependent. In this paper, we proposed a fully automatic system as a diagnostic support tool for the clinicians. For each Region Of Interest (ROI), a features set was extracted from low-energy and recombined images by using different techniques. A Random Forest classifier was trained on a selected subset of significant features by a sequential feature selection algorithm. The proposed Computer-Automated Diagnosis system is tested on 48 ROIs extracted from 53 patients referred to Istituto Tumori "Giovanni Paolo II" of Bari (Italy) from the breast cancer screening phase between March 2017 and June 2018. The present method resulted highly performing in the prediction of benign/malignant ROIs with median values of sensitivity and specificity of 87 . 5 % and 91 . 7 % , respectively. The performance was high compared to the state-of-the-art, even with a moderate/marked level of parenchymal background. Our classification model outperformed the human reader, by increasing the specificity over 8 % . Therefore, our system could represent a valid support tool for radiologists for interpreting CESM images, both reducing the false positive rate and limiting biopsies and surgeries.

Indexed as

background parenchymal enhancement (BPE)breast cancercomputer-automated diagnosis (CADx)contrast-enhanced spectral mammography (CESM)feature extractionmachine learning techniques

Identifiers

PMID31234363
PMCPMC6616937

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.