Evidence map›Paper›PMID 31234340›Full record

ArticleCancers2019

Development of a Prognostic Nomogram for Liver Metastasis of Uveal Melanoma Patients Selected by Liver MRI.

Pascale Mariani, Sylvain Dureau, Alexia Savignoni, Livia Lumbroso-Le Rouic, Christine Levy-Gabriel, Sophie Piperno-Neumann, Manuel J Rodrigues, Laurence Desjardins, Nathalie Cassoux, Vincent Servois

Abstract read
In one paragraph

Article in Cancers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Article
  3. Uveal Melanoma: Changing Paradigms of Treatment.Ocular oncology and pathology · 2026
    Review
  4. Review
  5. Article
  6. Intensive Surveillance and Aggressive Multimodal Treatment for Liver Metastases From Uveal Melanoma.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2025
    Article
  7. Article
  8. Article
  9. Scientific reports · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Uveal Melanoma.Cancers · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Pascale MarianiDepartment of Surgical Oncology, Institut Curie, 26 rue d'Ulm, 75248 Cedex 05 Paris, France. pascale.mariani@curie.fr.
Sylvain DureauDepartment of Biostatistic, Institut Curie, 26 rue d'Ulm, 75248 Cedex 05 Paris, France. sylvain.dureau@curie.fr.ORCID 0000-0002-7104-185X
Alexia SavignoniDepartment of Biostatistic, Institut Curie, 26 rue d'Ulm, 75248 Cedex 05 Paris, France. alexia.savignoni@curie.fr.
Livia Lumbroso-Le RouicDepartment of Surgical Oncology, Institut Curie, 26 rue d'Ulm, 75248 Cedex 05 Paris, France. livia.lumbroso@curie.fr.
Christine Levy-GabrielDepartment of Surgical Oncology, Institut Curie, 26 rue d'Ulm, 75248 Cedex 05 Paris, France. christine.levy@curie.fr.
Sophie Piperno-NeumannDepartment of Medical Oncology, Institut Curie, 26 rue d'Ulm, 75248 Cedex 05 Paris, France. sophie.piperno-neumann@curie.fr.
Manuel J RodriguesDepartment of Medical Oncology, Institut Curie, 26 rue d'Ulm, 75248 Cedex 05 Paris, France. manuel.rodrigues@curie.fr.ORCID 0000-0002-5443-0802
Laurence DesjardinsDepartment of Surgical Oncology, Institut Curie, 26 rue d'Ulm, 75248 Cedex 05 Paris, France. laurence.desjardins@curie.fr.
Nathalie CassouxDepartment of Surgical Oncology, Institut Curie, 26 rue d'Ulm, 75248 Cedex 05 Paris, France. nathalie.cassoux@curie.fr.
Vincent ServoisDepartment of Radiology, Institut Curie, 26 rue d'Ulm, 75248 Cedex 05 Paris, France. vincent.servois@curie.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with liver metastases of uveal melanoma (LMUM) die from their metastatic evolution within 2 years. We established a nomogram to choose a treatment adapted to life expectancy. From 2002 to 2013, we reviewed 224 patients with LMUM selected by liver MRI. A nomogram was developed based on a Cox model. The predictive performance of the model was assessed according to the C-statistic, Kaplan-Meier curve, and calibration plots. The median follow-up was 49.2 months (range, 0.6-70.9). The survival rates at 6, 12, and 24 months were 0.88 (0.95 CI [0.84-0.93]), 0.68 (0.95 CI [0.62-0.75]), and 0.26 (0.95 CI [0.21-0.33]), respectively. The four factors selected for the nomogram with a worse prognosis were: A disease-free interval between the UM and LMUM groups of less than 6 months (HR = 3.39; 0.95 CI [1.90-6.05]), more than 10 LMUM (HR = 3.95; 0.95 CI [1.97-4.43]), a maximum LMUM of more than 1200 mm2 (HR = 2.47; 0.95 CI [1.53-3.98]), and a lactate dehydrogenase (LDH) value greater than 1.5 (HR = 3.72; 0.95 CI [2.30-6.00]). The model achieved relatively good discrimination and calibration (C-statistic 0.71). This nomogram could be useful for decision-making and risk stratification for therapeutic options.

Indexed as

liver metastasisliver MRIprognostic factorstumour burdenuveal melanoma

Identifiers

PMID31234340
PMCPMC6627813

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.