Evidence map›Paper›PMID 31234307›Full record

ArticleJournal of clinical medicine2019

Sex Moderates the Effect of Aerobic Exercise on Some Aspects of Cognition in Cognitively Intact Younger and Middle-Age Adults.

Yaakov Stern, Seonjoo Lee, David Predovan, Richard P Sloan

Abstract read
In one paragraph

Article in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Longitudinal associations between self-reported exercise levels and cognition in ADAD.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  2. Interactive Relations of Body Mass Index, Cardiorespiratory Fitness, and Sex to Cognitive Function in Older Adults.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2024
    Article
  3. Sex and gender differences in cognitive resilience to aging and Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Exercise and Cognitive Function.Journal of clinical medicine · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yaakov SternDepartment of Neurology and Taub Institute, Cognitive Neuroscience Division, Columbia University, New York, NY 10032, USA. ys11@columbia.edu.ORCID 0000-0001-7542-3241
Seonjoo LeeMental Health Data Science, New York State Psychiatric Institute, New York, NY 10032, USA. sl3670@cumc.columbia.edu.
David PredovanDepartment of Neurology and Taub Institute, Cognitive Neuroscience Division, Columbia University, New York, NY 10032, USA. dp2931@cumc.columbia.edu.ORCID 0000-0002-1524-3262
Richard P SloanDepartment of Psychiatry, Division of Behavioral Medicine, Columbia University, New York, NY 10032, USA. rps7@cumc.columbia.edu.

Funding

Exercise, aging, and cognition: Effect and mechanismsR01AG033546 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SLOAN, RICHARD P, STERN, YAAKOV · 2010 to 2014
$4.9M
Statistical Methods for Neural Mechanisms Mediating Cognitive System in Mental Health ResearchK01AG051348 · NIA · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI LEE, SEONJOO · 2015 to 2018
$526k
NIA NIH HHS K01 AG051348NIA NIH HHS R01 AG033546
6 · The paper itself

Abstract

We recently reported the results of a randomized, parallel-group, observer-masked, community-based clinical trial of 132 cognitively normal individuals aged 20-67 with below median aerobic capacity who were randomly assigned to one of two 6-month, four-times-weekly conditions: aerobic exercise and stretching/toning. We now assessed potential sex moderation on exercise-related changes in aerobic capacity, BMI and cognitive function. There was no sex moderation of the effect of aerobic exercise on aerobic capacity or BMI. We had previously reported an effect of aerobic exercise on executive function that was moderated by age. We found additional moderation by sex, such that in any age range men improved more than women. Processing speed showed significant sex moderation but not significant age moderation. In men, processing speed significantly improved by week 12 (b = 0.35,

Indexed as

BMIexecutive functionprocessing speed

Identifiers

PMID31234307
PMCPMC6617072

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.