ArticleMarine drugs2019
Therapeutic Cell Protective Role of Histochrome under Oxidative Stress in Human Cardiac Progenitor Cells.
Open access · goldAbstract read
In one paragraph
Article in Marine drugs, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects.Signal transduction and targeted therapy · 2024Review
- Natural Substances vs. Approved Drugs in the Treatment of Main Cardiovascular Disorders-Is There a Breakthrough?Antioxidants (Basel, Switzerland) · 2023Review
- A Second Life for Seafood Waste: Therapeutical Promises of Polyhydroxynapthoquinones Extracted from Sea Urchin by-Products.Antioxidants (Basel, Switzerland) · 2023Article
- Development of Novel Pharmaceutical Forms of the Marine Bioactive Pigment Echinochrome A Enabling Alternative Routes of Administration.Marine drugs · 2023Article
- Marine-Derived Compounds Applied in Cardiovascular Diseases: Submerged Medicinal Industry.Marine drugs · 2023Review
- Targeting Ferroptosis as a Promising Therapeutic Strategy for Ischemia-Reperfusion Injury.Antioxidants (Basel, Switzerland) · 2022Review
- Echinochrome A Inhibits Melanogenesis in B16F10 Cells by Downregulating CREB Signaling.Marine drugs · 2022Article
- Marine Natural Products in Clinical Use.Marine drugs · 2022Review
- Biomaterials and Bioactive Natural Products from Marine Invertebrates: From Basic Research to Innovative Applications.Marine drugs · 2022Review
- Asiaticoside alleviates cardiomyocyte apoptosis and oxidative stress in myocardial ischemia/reperfusion injury via activating theAnnals of translational medicine · 2022Article
- Histochrome Attenuates Myocardial Ischemia-Reperfusion Injury by Inhibiting Ferroptosis-Induced Cardiomyocyte Death.Antioxidants (Basel, Switzerland) · 2021Article
- Multifaceted Clinical Effects of Echinochrome.Marine drugs · 2021Review
- Programmed cell death in stem cell-based therapy: Mechanisms and clinical applications.World journal of stem cells · 2021Review
- Proteomic Analysis of Hypoxia-Induced Senescence of Human Bone Marrow Mesenchymal Stem Cells.Stem cells international · 2021Article
- Isolation and Structure Determination of Echinochrome A Oxidative Degradation Products.Molecules (Basel, Switzerland) · 2020Article
- Engineered M13 Peptide Carrier Promotes Angiogenic Potential of Patient-Derived Human Cardiac Progenitor Cells and In Vivo Engraftment.Tissue engineering and regenerative medicine · 2020Article
- Selected Papers from the Third International Symposium on Life Science.Marine drugs · 2020Article
- Echinochrome A Reduces Colitis in Mice and Induces In Vitro Generation of Regulatory Immune Cells.Marine drugs · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 6 institutions in 2 countries.
Ji Hye ParkLaboratory of Regenerative Medicine and Stem Cell Biology, Department of Physiology, Medical Research Institute, School of Medicine, Pusan National University, Yangsan 50612, Korea. siwonvin@naver.com.
Na-Kyung LeeLaboratory of Regenerative Medicine and Stem Cell Biology, Department of Physiology, Medical Research Institute, School of Medicine, Pusan National University, Yangsan 50612, Korea. ahlng2005@naver.com.
Hye Ji LimLaboratory of Regenerative Medicine and Stem Cell Biology, Department of Physiology, Medical Research Institute, School of Medicine, Pusan National University, Yangsan 50612, Korea. dla9612@naver.com.
Sinthia MazumderLaboratory of Regenerative Medicine and Stem Cell Biology, Department of Physiology, Medical Research Institute, School of Medicine, Pusan National University, Yangsan 50612, Korea. sinthiambbs@gmail.com.
Vinoth Kumar RethineswaranLaboratory of Regenerative Medicine and Stem Cell Biology, Department of Physiology, Medical Research Institute, School of Medicine, Pusan National University, Yangsan 50612, Korea. vinrebha@gmail.com.
Yeon-Ju KimLaboratory of Regenerative Medicine and Stem Cell Biology, Department of Physiology, Medical Research Institute, School of Medicine, Pusan National University, Yangsan 50612, Korea. twou1234@nate.com.
Woong Bi JangLaboratory of Regenerative Medicine and Stem Cell Biology, Department of Physiology, Medical Research Institute, School of Medicine, Pusan National University, Yangsan 50612, Korea. jangwoongbi@naver.com.
Seung Taek JiLaboratory of Regenerative Medicine and Stem Cell Biology, Department of Physiology, Medical Research Institute, School of Medicine, Pusan National University, Yangsan 50612, Korea. jst5396@hanmail.net.
Songhwa KangLaboratory of Regenerative Medicine and Stem Cell Biology, Department of Physiology, Medical Research Institute, School of Medicine, Pusan National University, Yangsan 50612, Korea. songhwa.kang@gmail.com.
Da Yeon KimLaboratory of Regenerative Medicine and Stem Cell Biology, Department of Physiology, Medical Research Institute, School of Medicine, Pusan National University, Yangsan 50612, Korea. ekdus0258@gmail.com.
Le Thi Hong VanLaboratory of Regenerative Medicine and Stem Cell Biology, Department of Physiology, Medical Research Institute, School of Medicine, Pusan National University, Yangsan 50612, Korea. lethihongvan25121978@gmail.com.
Ly Thanh Truong GiangLaboratory of Regenerative Medicine and Stem Cell Biology, Department of Physiology, Medical Research Institute, School of Medicine, Pusan National University, Yangsan 50612, Korea. lythanhtruonggiang@gmail.com.
Dong Hwan KimDepartment of Neurosurgery & Medical Research Institute, Pusan National University Hospital, Busan 49241, Korea. smile0402@hanmail.net.
Jong Seong HaLaboratory of Regenerative Medicine and Stem Cell Biology, Department of Physiology, Medical Research Institute, School of Medicine, Pusan National University, Yangsan 50612, Korea. jongseong@pusan.ac.kr.
Jisoo YunLaboratory of Regenerative Medicine and Stem Cell Biology, Department of Physiology, Medical Research Institute, School of Medicine, Pusan National University, Yangsan 50612, Korea. jsyun14@hanmail.net.
Hyungtae KimDepartment of Thoracic and Cardiovascular Surgery, Pusan National University Yangsan Hospital, Yangsan 50612, Korea. 2719k@naver.com.
Jin HanNational Research Laboratory for Mitochondrial Signaling, Department of Physiology, Department of Health Sciences and Technology, BK21 Plus Project Team, Cardiovascular and Metabolic Disease Center, Inje University College of Medicine, Busan 47392, Korea. phyhanj@gmail.com.
Natalia P MishchenkoG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Science, Vladivostok 690022, Russia. mischenkonp@mail.ru.ORCID 0000-0001-7616-574X
Sergey A FedoreyevG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Science, Vladivostok 690022, Russia. fedoreev-s@mail.ru.
Elena A VasilevaG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Science, Vladivostok 690022, Russia. vasilieva_el_an@mail.ru.
Sang Mo KwonLaboratory of Regenerative Medicine and Stem Cell Biology, Department of Physiology, Medical Research Institute, School of Medicine, Pusan National University, Yangsan 50612, Korea. smkwon323@hotmail.com.
Sang Hong BaekDivision of Cardiology, Seoul St. Mary's Hospital, School of Medicine, the Catholic University of Korea, Seoul 06591, Korea. smkwon323@pusan.ac.kr.
Pusan National University · KRPacific Institute of Bioorganic Chemistry. GB Elyakova Far Eastern Branch of the Russian Academy of Sciences · RUPusan National University Hospital · KRInje University · KRPusan National University Yangsan Hospital · KRThe Catholic University of Korea Seoul St. Mary's Hospital · KR
Funding
Korean Health Technology R&D Project, Ministry of Health and Welfare HI17C1662Korean Health Technology R&D Project, Ministry of Health and Welfare HI18C2458Korean Health Technology R&D Project, Ministry of Health and Welfare HI18C2459Ministry of Science and Higher Education of the Russian Federation RFMEFI61317X0076National Research Foundation of Korea NRF - 2015M3A9B4066493National Research Foundation of Korea NRF - 2015R1A5A2009656National Research Foundation of Korea NRF - 2018R1A2B6006380
Abstract
Cardiac progenitor cells (CPCs) are resident stem cells present in a small portion of ischemic hearts and function in repairing the damaged heart tissue. Intense oxidative stress impairs cell metabolism thereby decreasing cell viability. Protecting CPCs from undergoing cellular apoptosis during oxidative stress is crucial in optimizing CPC-based therapy. Histochrome (sodium salt of echinochrome A-a common sea urchin pigment) is an antioxidant drug that has been clinically used as a pharmacologic agent for ischemia/reperfusion injury in Russia. However, the mechanistic effect of histochrome on CPCs has never been reported. We investigated the protective effect of histochrome pretreatment on human CPCs (hCPCs) against hydrogen peroxide (H
Indexed as
Annexin A5ApoptosisApoptosis Regulatory Proteinsbcl-2-Associated X ProteinCaspase 3Cells, CulturedCell SurvivalCellular SenescenceDNA DamageHumansHydrogen PeroxideMyocytes, CardiacNaphthoquinonesOxidative StressReperfusion InjuryRussiaAnnexin A5Apoptosis Regulatory Proteinsbcl-2-Associated X ProteinCaspase 3echinochrome AhistochromeHydrogen PeroxideNaphthoquinonescardiac progenitor cellscell therapyechinochrome Ahistochromeoxidative stress
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.