ReviewNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2020
Alcohol use disorder and sleep disturbances: a feed-forward allostatic framework.
Review in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 159 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
159 citing papers in PubMed, 5 syntheses or guidelines pooled it, 265 citations in OpenAlex.
- Advances in AI-Driven EEG Analysis for Neurological and Oculomotor Disorders: A Systematic Review.Biosensors · 2025Pooled it
- The Impact of Physical Activity on Sleep in Alcohol Users: A Systematic Review.Addiction biology · 2025Pooled it
- Objective and subjective measurement of sleep in people who use substances: Emerging evidence and recommendations from a systematic review.Journal of sleep research · 2025Pooled it
- Disruption of circadian rhythms promotes alcohol use: a systematic review.Alcohol and alcoholism (Oxford, Oxfordshire) · 2024Pooled it
- Sleep and the Pharmacotherapy of Alcohol Use Disorder: Unfortunate Bedfellows. A Systematic Review With Meta-Analysis.Frontiers in pharmacology · 2019Pooled it
- Effects of digital cognitive-behavioral therapy for insomnia in heavy drinkers with insomnia: A replication and extension study.Experimental and clinical psychopharmacology · 2026Trial
- Lactiplantibacillus plantarum Lp815 improves sleep and increases urinary GABA in a randomized, double-blind, placebo-controlled study of sleep disturbance.Scientific reports · 2026Trial
- Longitudinal changes in sleep quality in male patients with alcohol dependence receiving far-infrared ray therapy: associations with alterations in circulating pro-inflammatory cytokines.BMC psychiatry · 2025Trial
- Trial
- Influence of sleep quality on lapse to alcohol use during a quit attempt.Alcohol and alcoholism (Oxford, Oxfordshire) · 2024Trial
- Leveraging Ecological Momentary Assessment to Examine Bi-directional Associations Between Sleep Quality, Adolescent/Young Adult Alcohol Craving and Use.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2023Trial
- Effects of alcohol on sleep and nocturnal heart rate: Relationships to intoxication and morning-after effects.Alcoholism, clinical and experimental research · 2022Trial
- Evening binge alcohol disrupts cardiovagal tone and baroreflex function during polysomnographic sleep.Sleep · 2021Trial
- Insomnia treatment effects among young adult drinkers: Secondary outcomes of a randomized pilot trial.Alcoholism, clinical and experimental research · 2021Trial
- Trial
- Sleep as an Important Target or Modifier in Alcohol Use Disorder Clinical Treatment: Example From a Recent Gabapentin Randomized Clinical Trial.Journal of addiction medicineTrial
- Corticotropin-releasing hormone neurons in the bed nucleus of the stria terminalis control wakefulness in physiological and stressful conditions in mice.Molecular psychiatry · 2026Article
- Anterior cingulate cortex activation of claustrum projection neuron subtypes is enhanced by alcohol.Neuropharmacology · 2026Article
- Opposing Roles of CYP2E1 and ALDH2 in Binge Alcohol-Mediated Cerebellar Damage.International journal of molecular sciences · 2026Article
- Physical activity and sleep disturbances in individuals with alcohol use disorder: protocol of the APhysOH pilot study for a randomized controlled trial.Addiction science & clinical practice · 2026Article
99 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The development of alcohol use disorder (AUD) involves binge or heavy drinking to high levels of intoxication that leads to compulsive intake, the loss of control in limiting intake, and a negative emotional state when alcohol is removed. This cascade of events occurs over an extended period within a three-stage cycle: binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation. These three heuristic stages map onto the dysregulation of functional domains of incentive salience/habits, negative emotional states, and executive function, mediated by the basal ganglia, extended amygdala, and frontal cortex, respectively. Sleep disturbances, alterations of sleep architecture, and the development of insomnia are ubiquitous in AUD and also map onto the three stages of the addiction cycle. During the binge/intoxication stage, alcohol intoxication leads to a faster sleep onset, but sleep quality is poor relative to nights when no alcohol is consumed. The reduction of sleep onset latency and increase in wakefulness later in the night may be related to the acute effects of alcohol on GABAergic systems that are associated with sleep regulation and the effects on brain incentive salience systems, such as dopamine. During the withdrawal/negative affect stage, there is a decrease in slow-wave sleep and some limited recovery in REM sleep when individuals with AUD stop drinking. Limited recovery of sleep disturbances is seen in AUD within the first 30 days of abstinence. The effects of withdrawal on sleep may be related to the loss of alcohol as a positive allosteric modulator of GABA
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.