ArticlePediatric research2019
How skin anatomy influences transcutaneous bilirubin determinations: an in vitro evaluation.
Article in Pediatric research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Wearable Multispectral Sensor for Newborn Jaundice Monitoring.Sensors (Basel, Switzerland) · 2025Article
- Effect of skin color and other skin properties on the delivered light dose in phototherapy for neonatal hyperbilirubinemia.Biophotonics discovery · 2025Article
- Skin color influences transcutaneous bilirubin measurements: a systematic in vitro evaluation.Pediatric research · 2025Article
- Correlation of transcutaneous and serum bilirubin levels in late preterm and term neonates at a tertiary care center in south India.F1000Research · 2025Article
- Assessing accuracy of BiliPredics algorithm in predicting individual bilirubin progression in neonates-results from a prospective multi-center study.Frontiers in digital health · 2025Article
- Application of machine learning algorithms for accurate determination of bilirubin level on in vitro engineered tissue phantom images.Scientific reports · 2024Article
- Design and characterization of color printed polyurethane films as biomedical phantom layers.Biomedical optics express · 2023Article
- Article
- Quantification of cephalocaudal progression of jaundice in preterm infants.Pediatric research · 2023Article
- A Prospective Comparison of Serum and Transcutaneous Bilirubin in Indian Neonates.Journal of pediatric intensive care · 2022Article
- Inter-device reproducibility of transcutaneous bilirubin meters.Pediatric research · 2021Article
- Neonatal wearable device for colorimetry-based real-time detection of jaundice with simultaneous sensing of vitals.Science advances · 2021Article
- Accuracy of enhanced transcutaneous bilirubinometry according to various measurement sites.Turkish archives of pediatrics · 2021Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTranscutaneous bilirubinometry is an effective screening method for neonatal hyperbilirubinemia. Current transcutaneous bilirubin (TcB) meters are designed for the "standard" situation of TcB determinations on the forehead or sternum of term newborns. We hypothesize that skin anatomy can considerably influence TcB determinations in non-standard situations-e.g., on preterm newborns or alternative body locations.
methodsA commercially available TcB meter (JM-105) was evaluated in vitro on phantoms that accurately mimic neonatal skin. We varied the mimicked cutaneous hemoglobin content (0-2.5 g/L), bone depth (0.26-5.26 mm), and skin maturity-related light scattering (1.36-2.27 mm
resultsThe TcB meter adequately corrected for mimicked hemoglobin content. However, TcB determinations were influenced considerably by clinically realistic variations in mimicked bone depth and light scattering (deviations up to 72 µmol/L). This greatly exceeds the specified accuracy of the device (±25.5 µmol/L).
conclusionAs bone depth and light scattering vary with gestational maturity and body location, caretakers should be cautious when interpreting TcB measurements on premature newborns and non-standard body locations.
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