ArticleEndocrine connections2019
Prevalence of hypoglycaemia in a random population after Roux-en-Y gastric bypass after a meal test.
Article in Endocrine connections, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Incidence and risk factors of post-metabolic and bariatric surgery hypoglycemia: a systematic review.International journal of obesity (2005) · 2025Pooled it
- Post-bariatric Hypoglycemia Management: A Gulf Cooperation Council Consensus Statement.Journal of the Endocrine Society · 2026Article
- Nesidioblastosis in Patients With Severe Postbariatric Hypoglycemia: A Monocentric Case Series.Journal of the Endocrine Society · 2025Article
- Prevalence of dumping and hypoglycaemia symptoms after bariatric surgery: A questionnaire-based cross-sectional study.Clinical obesity · 2025Article
- Bariatric surgery and diabetes: Current challenges and perspectives.World journal of diabetes · 2024Review
- Society for Endocrinology guidelines for the diagnosis and management of post-bariatric hypoglycaemia.Endocrine connections · 2024Review
- Postprandial hypoglycemia as a complication of bariatric and metabolic surgery: a comprehensive review of literature.Frontiers in surgery · 2024Review
- Reliability of the DSS-Swe Questionnaire.Obesity surgery · 2023Article
- Mixed Meal Tolerance Test Versus Continuous Glucose Monitoring for an Effective Diagnosis of Persistent Post-Bariatric Hypoglycemia.Journal of clinical medicine · 2023Article
- Digital Solutions to Diagnose and Manage Postbariatric Hypoglycemia.Frontiers in nutrition · 2022Review
- Altered bile acid kinetics contribute to postprandial hypoglycaemia after Roux-en-Y gastric bypass surgery.International journal of obesity (2005) · 2021Article
- Do Gut Hormones Contribute to Weight Loss and Glycaemic Outcomes after Bariatric Surgery?Nutrients · 2021Review
- Diminished Counterregulatory Responses to Meal-Induced Hypoglycemia 4 Years After RYGB.Obesity surgery · 2021Article
- Patient involvement to inform the design of a clinical trial in postbariatric hypoglycaemia.BMC medical research methodology · 2020Article
- A Potential Role for Endogenous Glucagon in Preventing Post-Bariatric Hypoglycemia.Frontiers in endocrinology · 2020Article
- Brunner's Gland Hyperplasia in a Patient after Roux-Y Gastric Bypass: An Important Pitfall in GLP-1 Receptor Imaging.Case reports in endocrinology · 2020Article
- Diagnosis and Management of Post-Bariatric Hypoglycemia.Journal of the American Board of Family Medicine : JABFMReview
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveRoux-en-Y gastric bypass (RYGB) is an effective way to induce sustainable weight loss and can be complicated by postprandial hyperinsulinaemic hypoglycaemia (PHH). To study the prevalence and the mechanisms behind the occurrence of hypoglycaemia after a mixed meal tolerance test (MMTT) in patients with primary RYGB.
designThis is a cross-sectional study of patients 4 years after primary RYGB.
methodsFrom a total population of 550 patients, a random sample of 44 patients completed the total test procedures. A standardized mixed meal was used as stimulus. Venous blood samples were collected at baseline, every 10 min during the first half hour and every 30 min until 210 min after the start. Symptoms were assessed by questionnaires. Hypoglycaemia is defined as a blood glucose level below 3.3 mmol/L.
resultsThe prevalence of postprandial hypoglycaemia was 48% and was asymptomatic in all patients. Development of hypoglycaemia was more frequent in patients with lower weight at surgery (P = 0.045), with higher weight loss after surgery (P = 0.011), and with higher insulin sensitivity calculated by the homeostasis model assessment indexes (HOMA2-IR, P = 0.014) and enhanced beta cell function (insulinogenic index at 20 min, P = 0.001).
conclusionIn a randomly selected population 4 years after primary RYGB surgery, 48% of patients developed a hypoglycaemic event during an MMTT without symptoms, suggesting the presence of hypoglycaemia unawareness in these patients. The findings in this study suggest that the pathophysiology of PHH is multifactorial.
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