ArticleNeuroImage. Clinical2019
Characterizing a perfusion-based periventricular small vessel region of interest.
Article in NeuroImage. Clinical, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Sex Differences in Cerebral Small Vessel Disease: A Systematic Review and Meta-Analysis.Frontiers in neurology · 2021Pooled it
- Associations Between White Matter Hyperintensity Burden, Cerebral Blood Flow and Transit Time in Small Vessel Disease: An Updated Meta-Analysis.Frontiers in neurology · 2021Pooled it
- Magnetic Resonance Imaging in Cerebral Small Vessel Disease-Related Depression: From Visual Scoring to Artificial Intelligence.CNS neuroscience & therapeutics · 2026Review
- Cerebral perfusion features linking subclinical cardiac and aortic dysfunction to vascular brain injury.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Time-restricted feeding rejuvenates cerebrovascular function and preserves cognition during aging.Research square · 2026Article
- Correlation analysis of serum 25(OH)D levels with white matter hyperintensities and gait disorders in patients with cerebral small vessel disease.Scientific reports · 2026Article
- Article
- Periventricular radionecrosis after conventionally fractionated radiation for low grade meningiomas.Radiation oncology (London, England) · 2025Article
- Associations Between Retinal Microvasculature, Orbital Blood Flow, and Cerebral Blood Flow in Healthy Adults.Investigative ophthalmology & visual science · 2025Article
- Machine learning prediction model for functional prognosis of acute ischemic stroke based on MRI radiomics of white matter hyperintensities.BMC medical imaging · 2025Article
- Regional cerebral blood flow reflects both neurodegeneration and microvascular integrity across the Alzheimer's continuum.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Automated Quality Evaluation Index for Arterial Spin Labeling Derived Cerebral Blood Flow Maps.Journal of magnetic resonance imaging : JMRI · 2024Article
- Non-invasive Assessment of Cerebral Hemodynamics Using Resting-State Functional Magnetic Resonance Imaging in Multiple Sclerosis and Age-Related White Matter Lesions.Human brain mapping · 2024Article
- Reproducibility of arterial spin labeling cerebral blood flow image processing: A report of the ISMRM open science initiative for perfusion imaging (OSIPI) and the ASL MRI challenge.Magnetic resonance in medicine · 2024Article
- Impact of white matter hyperintensities on structural connectivity and cognition in cognitively intact ADNI participants.Neurobiology of aging · 2024Article
- Associations between cerebral blood flow and progression of white matter hyperintensities.Frontiers in neuroimaging · 2024Article
- Imaging the neurovascular unit in health and neurodegeneration: a scoping review of interdependencies between MRI measures.Fluids and barriers of the CNS · 2023Article
- Deep Medullary Vein and MRI Markers Were Related to Cerebral Hemorrhage Subtypes.Brain sciences · 2023Article
- Current state and guidance on arterial spin labeling perfusion MRI in clinical neuroimaging.Magnetic resonance in medicine · 2023Article
- Regional contribution of vascular dysfunction in white matter dementia: clinical and neuropathological insights.Frontiers in neurology · 2023Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
The periventricular white matter (PVWM) is supplied by terminal distributions of small vessels and is particularly susceptible to developing white matter lesions (WML) associated with cerebral small vessel disease (CSVD). We obtained group-averaged cerebral blood flow (CBF) maps from Arterial Spin Labeled (ASL) perfusion MRI data obtained in 436 middle-aged (50.4 ± 3.5 years) subjects in the NHLBI CARDIA study and in 61 elderly (73.3 ± 6.9 years) cognitively normal subjects recruited from the Penn Alzheimer's Disease Center (ADC) and found that the lowest perfused brain voxels are located within the PVWM. We constructed a white matter periventricular small vessel (PSV) region of interest (ROI) by empirically thresholding the group averaged CARDIA CBF map at CBF < 15 ml/100 g/min. Thereafter we compared CBF in the PSV ROI and in the remaining white matter (RWM) with the location and volume of WML measured with Fluid Attenuated Inversion Recovery (FLAIR) MRI. WM CBF was lower within WML than outside WML voxels (p < <0.0001) in both the PSV and RWM ROIs, however this difference was much smaller (p < <0.0001) in the PSV ROI than in the RWM suggesting a more homogenous reduction of CBF in the PSV region. Normalized WML volumes were significantly higher in the PSV ROI than in the RWM and in the elderly cohort as compared to the middle-aged cohort (p < <0.0001). Additionally, the PSV ROI showed a significantly (p = .001) greater increase in lesion volume than the RWM in the elderly ADC cohort than the younger CARDIA cohort. Considerable intersubject variability in PSV CBF observed in both study cohorts likely represents biological variability that may be predictive of future WML and/or cognitive decline. In conclusion, a data-driven PSV ROI defined by voxels with low perfusion in middle age defines a region with homogeneously reduced CBF that is particularly susceptible to progressive ischemic injury in elderly controls. PSV CBF may provide a mechanistically specific biomarker of CSVD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.