Evidence map›Paper›PMID 31233744›Full record

ArticleChest2019

Objectively Measured Chronic Lung Injury on Chest CT.

Rola Harmouche, Samuel Y Ash, Rachel K Putman, Gary M Hunninghake, Ruben San Jose Estepar, Fernando J Martinez, Augustine M Choi, David A Lynch, Hiroto Hatabu, MeiLan K Han and 6 more

Open access · greenAbstract read
In one paragraph

Article in Chest, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Radiomics and Artificial Intelligence in Pulmonary Fibrosis.Journal of imaging informatics in medicine · 2025
    Review
  3. Article
  4. Approach to Clinical Trials for the Prevention of Pulmonary Fibrosis.Annals of the American Thoracic Society · 2023
    Article
  5. Article
  6. Article
  7. Article
  8. Defining Resilience: A Critical Step to Promote Respiratory Health.Annals of the American Thoracic Society · 2021
    Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 1 country.

Rola HarmoucheApplied Chest Imaging Laboratory, Brigham and Women's Hospital; Boston, MA.
Samuel Y AshApplied Chest Imaging Laboratory, Brigham and Women's Hospital; Boston, MA; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA. Electronic address: syash@bwh.harvard.edu.
Rachel K PutmanDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA.
Gary M HunninghakeDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA.
Ruben San Jose EsteparApplied Chest Imaging Laboratory, Brigham and Women's Hospital; Boston, MA.
Fernando J MartinezDepartment of Medicine, Weil Cornell Medical College, New York, NY.
Augustine M ChoiDepartment of Medicine, Weil Cornell Medical College, New York, NY.
David A LynchDepartment of Radiology, National Jewish Health, Denver, CO.
Hiroto HatabuDepartment of Radiology, Brigham and Women's Hospital, Boston, MA.
MeiLan K HanDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI.
Russell P BowlerDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, National Jewish Health, Denver, CO.
Ravi KalhanDivision of Pulmonary and Critical Care Medicine, Departments of Medicine and Preventative Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL.
Ivan O RosasApplied Chest Imaging Laboratory, Brigham and Women's Hospital; Boston, MA.
George R WashkoApplied Chest Imaging Laboratory, Brigham and Women's Hospital; Boston, MA; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA.
Raul San Jose EsteparApplied Chest Imaging Laboratory, Brigham and Women's Hospital; Boston, MA.
COPDGene Investigators
Brigham and Women's Hospital · USCornell University · USUniversity of Colorado Denver · USNorthwestern University · USUniversity of Michigan–Ann Arbor · US

Funding

Genetic Epidemiology of COPDU01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2007 to 2021
$56.9M
Metabolomic signatures of empysema and COPD progression in the COPDGene cohortR01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2012 to 2016
$31.1M
Respiratory Computational Discovery CoreP01HL114501 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI CHOI, MARY E · 2013 to 2025
$24.9M
Genetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7M
(2 of 2) Genetic Epidemiology of COPDR01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2012 to 2016
$18.9M
Transitions from Impaired Respiratory Health to Lung DiseaseR01HL122477 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI RAVI KALHAN · 2014 to 2026
$17.3M
RESPIRATORY RESEARCHT32HL007633 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI George R Washko · 1985 to 2026
$14.9M
Clinical Genetics and Screening for Pulmonary FibrosisR01HL130974 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI GARY MATTHEW HUNNINGHAKE, Benjamin Alexander Raby · 2016 to 2026
$10.0M
Genetic and Genomic Characterization of the Occurrence and Progression of Interstitial Lung AbnormalitiesR01HL135142 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MICHAEL H. CHO, GARY MATTHEW HUNNINGHAKE · 2017 to 2026
$7.7M
Interstitial Lung Abnormalities: Defining the Phenotype, Causes, and Consequences.R01HL111024 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI HUNNINGHAKE, GARY MATTHEW · 2013 to 2022
$6.4M
von Willebrand Factor in Sickle Cell Disease PathophysiologyR01HL112633 · NHLBI · BLOODWORKS · PI LOPEZ, JOSE ARON · 2012 to 2018
$5.3M
Airway Inspector: a chest imaging biomarker software platform for COPDR01HL116931 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SAN JOSE ESTEPAR, RAUL · 2013 to 2017
$2.2M
NHLBI NIH HHS K08 HL145118NHLBI NIH HHS L30 HL134158NHLBI NIH HHS P01 HL114501NHLBI NIH HHS R01 HL089856NHLBI NIH HHS R01 HL089897NHLBI NIH HHS R01 HL107246NHLBI NIH HHS R01 HL111024NHLBI NIH HHS R01 HL112633NHLBI NIH HHS R01 HL116931NHLBI NIH HHS R01 HL122477NHLBI NIH HHS R01 HL130974NHLBI NIH HHS R01 HL135142NHLBI NIH HHS R21 HL140422NHLBI NIH HHS T32 HL007633NHLBI NIH HHS U01 HL089856NHLBI NIH HHS U01 HL089897
6 · The paper itself

Abstract

backgroundTobacco smoke exposure is associated with emphysema and pulmonary fibrosis, both of which are irreversible. We have developed a new objective CT analysis tool that combines densitometry with machine learning to detect high attenuation changes in visually normal appearing lung (Norm

methodsWe trained the classification tool by placing 34,528 training points in chest CT scans from 297 COPDGene participants. The tool was then used to classify lung tissue in 9,038 participants as normal, emphysema, fibrotic/interstitial, or Norm

resultsA higher percentage of lung occupied by Norm

conclusionsA new class of Norm

Indexed as

Tomography, X-Ray ComputedAgedFemaleHumansLung Diseases, InterstitialLung InjuryMaleMiddle AgedPulmonary EmphysemaPulmonary Fibrosiscomputed tomographyemphysemalung injurypulmonary fibrosis

Identifiers

PMID31233744
PMCPMC6904856
OpenAlexW2950106091

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.