ArticlePloS one2019
Genetic diversity of Ascaris spp. infecting humans and pigs in distinct Brazilian regions, as revealed by mitochondrial DNA.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 33 citations in OpenAlex.
- Molecular characterization of the prevalent soil-transmitted helminths in Narathiwat Province, southern Thailand.PloS one · 2026Article
- Hybrid and/or mixed infection by pig and human Ascaris in a Guarani indigenous village in southern Brazil.PLoS neglected tropical diseases · 2025Article
- Dose-response effects of multiple Ascaris suum exposures and their impact on lung protection during larval ascariasis.PLoS neglected tropical diseases · 2024Article
- Worldwide absence of canonical benzimidazole resistance-associated mutations within β-tubulin genes from Ascaris.Parasites & vectors · 2024Article
- A Comparison of the Prevalence of Gastrointestinal Parasites in Wild Boar (Animals : an open access journal from MDPI · 2024Article
- Effect of Selected Entomopathogenic Fungal Species on Embryonic Development ofAnimals : an open access journal from MDPI · 2023Article
- Zoonotic Parasites in Artiodactyls with Emphasis on the Feral Boar in the Atlantic Forest, State of Rio de Janeiro, Brazil.Animals : an open access journal from MDPI · 2023Article
- A molecular and morphological study of Ascaris suum in a human-pig contact scenario in northeastern Brazil.Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria · 2023Article
- Family-Run Pig Farms: Research and Extension Activities for Parasite Control in a Municipality in the State of Rio de Janeiro, Brazil.Pathogens (Basel, Switzerland) · 2022Article
- Development of allele-specific PCR methodology (AS-PCR) to screening A. lumbricoides and A. suum.Parasitology research · 2022Article
- Burdens of Ascaris spp. and Cryptosporidium spp. parasites in farm pigs in Ghana.Veterinary medicine and science · 2022Article
- Prevalence of intestinal parasitic infections versus knowledge, attitudes and practices of male residents in Brazilian urban slums: a cross-sectional study.Revista do Instituto de Medicina Tropical de Sao Paulo · 2022Article
- Morphologic Characterization of Strongylida Larvae from Human and Swine Coprocultures in Rural Communities in the State of Piauí, Northeastern Brazil.Journal of tropical medicine · 2022Article
- The epidemiology of soil-transmitted helminth infections in children up to 8 years of age: Findings from an Ecuadorian birth cohort.PLoS neglected tropical diseases · 2021Article
- Ascariasis in a 75-year-old man with small bowel volvulus: a case report.BMC infectious diseases · 2021Article
- Article
- Whipworm and roundworm infections.Nature reviews. Disease primers · 2020Review
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, we assessed the genetic diversity of Ascaris lumbricoides / Ascaris suum circulating in humans and pigs, exploring potential zoonotic cycles in endemic areas in Brazil. We carried out cross-sectional surveys in four municipalities: Santa Isabel do Rio Negro (SIRN-AM) (n = 328); Nossa Senhora de Nazaré (NSN-PI) and Teresina (TER-PI) (n = 605 and n = 297, respectively); and Cachoeiras de Macacu (CAM-RJ) (n = 543). We also studied 61 fecal samples/adult worms obtained from pigs (n = 53 in NSN-PI and n = 8 in TER-PI). A ~450 bp fragment of the Ascaris cytochrome c oxidase subunit 1 (cox1) and ~400 bp of the NADH dehydrogenase subunit 1 (nad1) were amplified and sequenced. Maximum-likelihood (ML) tree and Median-joining (MJ) haplotype network analyses were performed. We also performed scanning electron micrographs of adult specimens. Positivity rates were 93/328 (28.4%) in SIRN-AM, 6/297 (2.0%) in TER-PI, 0/605 (0%) in NSN-PI, and 6/543 (1.1%) in CAM-RJ. In NSN-PI it reached 11/53 (20.7%) in pigs. The MJ network based on cox1 locus (383 bp) revealed three main clusters, one centered around haplotypes H01/H28/H32 and the other around H07/H11. The cox1 haplotypes had a heterogeneous distribution, showing no pattern by geographic region, and high haplotype diversity. The ML trees based on cox1 and nad1 loci showed a similar topology with each other, and with the haplotype networks. Three distinct clusters were observed. Sequences of cox1 and nad1 from humans and animals were distributed throughout the tree and it was not possible to differentiate specimens of human and swine origin. Ascaris populations obtained from humans and swine in different Brazilian regions are not discriminable through the genetic markers used, which indicates the potential for zoonotic transmission and the need for better control of these infections in swine herds, mainly when created in a peridomestic environment.
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