Evidence map›Paper›PMID 31233508›Full record

ArticlePloS one2019

Inhibition of inflammation by minocycline improves heart failure and depression-like behaviour in rats after myocardial infarction.

Hong-Wei Wang, Monir Ahmad, Rami Jadayel, Fatimah Najjar, Diane Lagace, Frans H H Leenen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 41 citations in OpenAlex.

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  9. Neuroimmunology of Cardiovascular Disease.Current hypertension reports · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Hong-Wei WangBrain and Heart Research Group, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
Monir AhmadBrain and Heart Research Group, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
Rami JadayelBrain and Heart Research Group, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
Fatimah NajjarBrain and Heart Research Group, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
Diane LagaceNeuroscience Research Program, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Frans H H LeenenBrain and Heart Research Group, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.ORCID 0000-0001-8497-4416
University of Ottawa · CA

Funding

CIHR MOP-136923
6 · The paper itself

Abstract

rationalePatients with heart failure have an increased incidence of depression. Central and peripheral inflammation play a major role in the pathophysiology of both heart failure and depression.

aimMinocycline is an antibiotic that inhibits microglia activation and release of pro-inflammatory cytokines. We assessed effects of minocycline on extent of heart failure and depression at 2 and 8 weeks post myocardial infarction. METHODS/

resultsMale Wistar rats were randomly divided into 3 groups: (i) sham + vehicle; (ii) MI + vehicle; and (iii) MI + minocycline with n/group of 8, 9 and 9 at 2 weeks, and 10, 16, 8 at weeks, respectively. Oral minocycline (50 mg/kg/day) or vehicle started 2 days before surgery. Depression-like behaviour was assessed with sucrose preference and forced swim tests, and cardiac function with echo and hemodynamics. After myocardial infarction, microglia activation and plasma/brain pro-inflammatory cytokines increased, which were mostly prevented by minocycline. At 8 weeks, cardiac dysfunction was attenuated by minocycline: infarct size (MI + Vehicle 29±1, MI + Min 23±1%), ejection fraction (Sham 80±1, MI + Vehicle 48±2, MI + Min 58±2%) and end diastolic pressure (Sham 3.2±0.3, MI + Vehicle 18.2±1.1, MI + Min 8.5±0.9 mm Hg). Depression-like behaviour was significantly improved by minocycline in sucrose preference test (% Sucrose Intake: Sham 96±1, MI + Vehicle 78±2, MI + Min 87±2) and forced swim test (% Immobile: Sham 40±4, MI + Vehicle 61±3, MI + Min 37±6).

conclusionRats post myocardial infarction develop systemic inflammation, heart failure and depression-like behaviour that are all attenuated by minocycline. Targeting (neuro) inflammation may represent new therapeutic strategy for patients with heart failure and depression.

Indexed as

AnimalsCytokinesDepressionHeart FailureInflammationMaleMinocyclineMyocardial InfarctionRatsRats, WistarCytokinesMinocycline

Identifiers

PMID31233508
PMCPMC6590948
OpenAlexW2954998565

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.