ArticlePLoS genetics2019
Host-dependent nitrogen recycling as a mechanism of symbiont control in Aiptasia.
Article in PLoS genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
47 citing papers in PubMed, 118 citations in OpenAlex.
- Symbiosis collapses during development of asexual offspring in the absence of heterotrophic feeding in a model cnidarian-algal symbiosis.Scientific reports · 2026Article
- Function and Development of Deep-sea Mussel Bacteriocytes Revealed by snRNA-seq and Spatial Transcriptomics.Genomics, proteomics & bioinformatics · 2026Article
- Heterotrophy and symbiosis affect energy reserves for pedal lacerates in the sea anemonePeerJ · 2026Article
- Limited contributions of bacteria and fungi to coral nutrition revealed by amino acid δCommunications biology · 2025Article
- Stability of the cnidarian-dinoflagellate symbiosis is primarily determined by symbiont cell-cycle arrest.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The Influence of Symbiont Identity on the Proteomic and Metabolomic Responses of the Model Cnidarian Aiptasia to Thermal Stress.Environmental microbiology · 2025Article
- Anemonefish use sialic acid metabolism as Trojan horse to avoid giant sea anemone stinging.BMC biology · 2025Article
- Destabilization of mutualistic interactions shapes the early heat stress response of the coral holobiont.Microbiome · 2025Article
- Cell type-specific immune regulation under symbiosis in a facultatively symbiotic coral.The ISME journal · 2025Article
- Coral larvae increase nitrogen assimilation to stabilize algal symbiosis and combat bleaching under increased temperature.PLoS biology · 2024Article
- Trade-off between photosymbiosis and innate immunity influences cnidarian's response to pathogenic bacteria.Proceedings. Biological sciences · 2024Article
- Article
- Photosymbiosis reduces the environmental stress response under a heat challenge in a facultatively symbiotic coral.Scientific reports · 2024Article
- Comparative transcriptomics revealed parallel evolution and innovation of photosymbiosis molecular mechanisms in a marine bivalve.Proceedings. Biological sciences · 2024Article
- Comparative physiology reveals heat stress disrupts acid-base homeostasis independent of symbiotic state in the model cnidarian Exaiptasia diaphana.The Journal of experimental biology · 2024Article
- Two horizontally acquired bacterial genes steer the exceptionally efficient and flexible nitrogenous waste cycling in whiteflies.Science advances · 2024Article
- Abundance of Oligoflexales bacteria is associated with algal symbiont density, independent of thermal stress inEcology and evolution · 2023Article
- A carbon-nitrogen negative feedback loop underlies the repeated evolution of cnidarian-Symbiodiniaceae symbioses.Nature communications · 2023Article
- Coupled carbon and nitrogen cycling regulates the cnidarian-algal symbiosis.Nature communications · 2023Article
- Unfolding the secrets of microbiome (Symbiodiniaceae and bacteria) in cold-water coral.Microbiology spectrum · 2023Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The metabolic symbiosis with photosynthetic algae allows corals to thrive in the oligotrophic environments of tropical seas. Different aspects of this relationship have been investigated using the emerging model organism Aiptasia. However, many fundamental questions, such as the nature of the symbiotic relationship and the interactions of nutrients between the partners remain highly debated. Using a meta-analysis approach, we identified a core set of 731 high-confidence symbiosis-associated genes that revealed host-dependent recycling of waste ammonium and amino acid synthesis as central processes in this relationship. Subsequent validation via metabolomic analyses confirmed that symbiont-derived carbon enables host recycling of ammonium into nonessential amino acids. We propose that this provides a regulatory mechanism to control symbiont growth through a carbon-dependent negative feedback of nitrogen availability to the symbiont. The dependence of this mechanism on symbiont-derived carbon highlights the susceptibility of this symbiosis to changes in carbon translocation, as imposed by environmental stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.