ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2020
Dissociable cognitive patterns related to depression and anxiety in multiple sclerosis.
Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Effects of mindfulness-based interventions on cognition in people with multiple sclerosis: a systematic review and meta-analysis of randomized controlled trials.Frontiers in psychiatry · 2024Pooled it
- Impact of mindfulness training on emotion regulation in multiple sclerosis: Secondary analysis of a pilot randomized controlled trial.Rehabilitation psychology · 2022Trial
- Evaluating Cognitive Outcomes in Multiple Sclerosis: Real-World Impact of Ozanimod on Processing Speed Using BICAMS.Neurology and therapy · 2025Article
- The protective role of cognitive reserve in moderating depressive symptomatology in patients with multiple sclerosis.BMC psychology · 2025Article
- Cognitive impairment, mood, and fatigue in various multiple sclerosis subtypes: a one-year follow-up study.Journal of neurology · 2025Article
- Anxiety and Cognition in Multiple Sclerosis: A Narrative Review.International journal of MS care · 2025Review
- Biomarkers and Rehabilitation for Functional Neurological Disorder.Journal of personalized medicine · 2024Review
- The influence of depression and anxiety on cognition in people with multiple sclerosis: a cross-sectional analysis.Journal of neurology · 2024Article
- Observational
- Cognitive profile in multiple sclerosis and post-COVID condition: a comparative study using a unified taxonomy.Scientific reports · 2024Article
- Predictive Model of Anxiety and Depression Perception in Multiple Sclerosis Patients: Possible Implications for Clinical Treatment.Bioengineering (Basel, Switzerland) · 2024Article
- Impact of depression on the perception of fatigue and information processing speed in a cohort of multiple sclerosis patients.BMC psychology · 2023Article
- Early Predictors of Disability and Cognition in Multiple Sclerosis Patients: A Long-Term Retrospective Analysis.Journal of clinical medicine · 2023Article
- Relationship of Motor Impairment with Cognitive and Emotional Alterations in Patients with Multiple Sclerosis.International journal of environmental research and public health · 2023Observational
- Etiology, effects and management of comorbidities in multiple sclerosis: recent advances.Frontiers in immunology · 2023Review
- A promising cognitive screener in multiple sclerosis: The NIH toolbox cognition battery concords with gold standard neuropsychological measures.Multiple sclerosis (Houndmills, Basingstoke, England) · 2022Article
- Cognitive Relapse in Multiple Sclerosis: New Findings and Directions for Future Research.NeuroSci · 2022Review
- Machine learning to investigate superficial white matter integrity in early multiple sclerosis.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2022Article
- Effects of Vascular Comorbidity on Cognition in Multiple Sclerosis Are Partially Mediated by Changes in Brain Structure.Frontiers in neurology · 2022Article
- Real-time associations among MS symptoms and cognitive dysfunction using ecological momentary assessment.Frontiers in medicine · 2022Article
Corrections and comments
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Authors and funding
16 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundIndividuals with multiple sclerosis (MS) frequently present with depression and anxiety, as well as cognitive impairment, challenging clinicians to disentangle interrelationships among these symptoms.
objectiveTo identify cognitive functions associated with anxiety and depression in MS.
methodsMood and cognition were measured in 185 recently diagnosed patients (Reserve Against Disability in Early Multiple Sclerosis (RADIEMS) cohort), and an independent validation sample (MEM CONNECT cohort,
resultsIn RADIEMS cohort, lower anxiety was associated with better nonverbal memory (
conclusionConsistent mood-cognition relationships were identified in two independent cohorts of MS patients, suggesting that cognitive correlates of anxiety and depression are separable. This dissociation may support more precise models to inform treatment development. Treatment of mood symptoms may mitigate effects on cognition and/or treatment of cognition may mitigate effects on mood.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.