Evidence map›Paper›PMID 31233254›Full record

ArticleStem cells (Dayton, Ohio)2019

Canonical Wnt Signaling Promotes Neovascularization Through Determination of Endothelial Progenitor Cell Fate via Metabolic Profile Regulation.

Yan Shao, Jianglei Chen, Willard Freeman, Li-Jie Dong, Zhi-Hui Zhang, Manhong Xu, Fangfang Qiu, Yanhong Du, Juping Liu, Xiao-Rong Li and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Stem cells (Dayton, Ohio), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
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  4. Endothelial progenitor cells in pregnancy-related diseases.Clinical science (London, England : 1979) · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Yan ShaoEye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China.
Jianglei ChenDepartment of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Willard FreemanDepartment of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Li-Jie DongEye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China.
Zhi-Hui ZhangEye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China.
Manhong XuEye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China.
Fangfang QiuDepartment of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Yanhong DuDepartment of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Juping LiuEye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China.
Xiao-Rong LiEye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China.
Jian-Xing MaDepartment of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.ORCID 0000-0001-8815-1716
Tianjin Medical University Eye Hospital · CNUniversity of Oklahoma Health Sciences Center · US

Funding

Targeted DNA Methylation and Mitochondrial Heteroplasmy CoreP30AG050911 · NIA · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI HOLLY VAN REMMEN · 2015 to 2026
$13.9M
A new pathogenic mechanism for diabetic retinopathyR01EY019309 · NEI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Jian-Xing Jay Ma · 2009 to 2026
$6.1M
STUDIES OF RPE65R01EY012231 · NEI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MA, JIAN-XING, MOISEYEV, GENNADIY · 1998 to 2021
$5.7M
Pilot Project ProgramP30GM122744 · NIGMS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI MA, JIAN-XING · 2017 to 2021
$5.5M
The wnt signaling pathway in choroidal neovascularizationR01EY018659 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI MA, JIAN-XING · 2009 to 2019
$3.7M
A Novel Pathogenic Pathway for Diabetic KeratopathyR01EY028949 · NEI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Dimitrios Karamichos, Jian-Xing Jay Ma · 2018 to 2026
$2.2M
NEI NIH HHS R01 EY012231NEI NIH HHS R01 EY018659NEI NIH HHS R01 EY019309NEI NIH HHS R01 EY028949NIA NIH HHS P30 AG050911NIGMS NIH HHS P30 GM122744
6 · The paper itself

Abstract

Endothelial progenitor cells (EPCs) contribute to blood vessel formation. Canonical Wnt signaling plays an important role in physiological and pathological angiogenesis and EPC fate regulation. However, the mechanism for Wnt signaling to regulate EPC fate in neovascularization (NV) has not been clearly defined. Here, we showed that very low-density lipoprotein receptor knockout (Vldlr

Indexed as

AnimalsCell DifferentiationCells, CulturedDisease Models, AnimalEndothelial Progenitor CellsMetabolomeMiceNeovascularization, PathologicStem CellsWnt Signaling PathwayEndothelial progenitor cellsGlycolysisMitochondriaNeovascularizationWnt signaling

Identifiers

PMID31233254
PMCPMC6851557
OpenAlexW2949312182

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.