ArticleThe journal of nutrition, health & aging2019
HDL Cholesterol Is Independently Associated with Cognitive Function in Males But Not in Females within a Cohort of Nonagenarians: The MUGELLO Study.
Article in The journal of nutrition, health & aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Article
- The association between atherogenic index of plasma and cognitive impairment among older adults in Southern Iran: findings from the Bushehr elderly health program.BMC geriatrics · 2025Article
- Sex-specific associations between serum lipid levels and cognitive performance in older adults: results from a cross-sectional real-world study.Aging clinical and experimental research · 2025Article
- HDL Function across the Lifespan: From Childhood, to Pregnancy, to Old Age.International journal of molecular sciences · 2023Review
- Association between Serum Lipid Parameters and Cognitive Performance in Older Adults.Journal of clinical medicine · 2021Article
- Relationships of Lipids Profile with Health-Related Quality of Life in Chinese Centenarians.The journal of nutrition, health & aging · 2020Article
- Nutrient Patterns, Cognitive Function, and Decline in Older Persons: Results from the Three-City and NuAge Studies.Nutrients · 2019Article
- Plasma NfL and cognitive functioning in older adults: The moderating role of HDL cholesterol.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- Blood lipids as accessible biomarkers for early dementia risk screening: Bridging diagnostic gaps in resource-limited settings.Journal of Alzheimer's disease reportsReview
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4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo investigate the possible relationship between lipid profile and cognitive functions in a cohort of nonagenarians enrolled within the Mugello Study, an epidemiological study aimed at investigating both clinically relevant geriatric items and various health issues.
designCross-sectional survey.
settingThis study focused on oldest old community-dwelling participants.
participantsThree hundred twenty-five nonagenarians (218 F, median age: 92 years). MEASUREMENTS: Participants were evaluated through laboratory, instrumental examinations and questionnaires concerning lifestyle, dietary habits and cognitive status.
resultsFemales are older, with a lower level of education, live more prevalently on their own and have higher values for total cholesterol and high-density lipoprotein cholesterol (HDL) compared to males. With regard to functional and cognitive measures females report a significantly lower skill level in the physical activity performance, with a level of independence that is better for both basic and instrumental activities. In order to investigate whether there was an association between lipid variables and cognitive function as measured by the Mini-Mental State Examination a multiple regression analysis was performed with adjustments for confounding variables based on gender. In males, HDL cholesterol showed a significant relationship with Mini-Mental State Examination after a complete adjustment with years of education, physical activity performance and daily living activities (β = 0.174; p=0.037). In females HDL cholesterol showed a significant association only in the model adjusted for age and body mass index, losing its associations as soon as the cohabitation state and the depression status entered the model.
conclusionOur results support the hypothesis that HDL cholesterol is significantly linked to cognitive functions, especially in males of a cohort of very old people.
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