Evidence map›Paper›PMID 31233073›Full record

SynthesisThe journal of nutrition, health & aging2019

Sarcopenia Is Associated with Cognitive Impairment in Older Adults: A Systematic Review and Meta-Analysis.

G Cabett Cipolli, M Sanches Yassuda, I Aprahamian

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The journal of nutrition, health & aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

G Cabett CipolliIvan Aprahamian, MD, MS, PhD, FACP. Group of Investigation on Multimorbidity and Mental Health in Aging (GIMMA), Internal Medicine Department, Faculty of Medicine of Jundiaí, Jundiaí, Brazil. 250 Francisco Telles street. ZIP 13.202-550. E-mail: ivan.aprahamian@gmail.com.
M Sanches Yassuda
I Aprahamian

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesThere is little evidence in the literature about the possible relationship between sarcopenia and cognition in older adults. Our objective was to investigate the association between cognitive impairment and sarcopenia in older adults living in the community through a systematic review of published studies. RESEARCH DESIGN AND

methodsWe performed a systematic review with meta-analysis through Pubmed, LILACS, Scielo and Web of Science databases between March 1, 2001 and December 18, 2018. We included longitudinal and cross-sectional studies that evaluated sarcopenia and cognition as a primary objective.

resultsOf the 274 studies identified by the systematic review, 10 were included in qualitative analysis (total of 9,703 participants), and 6 were eligible for the meta-analysis (n = 7,045). Mean prevalence of sarcopenia was 10.5%. Cognitive impairment was observed in 269 participants with sarcopenia (40%), compared with 1,616 in non-sarcopenic participants (25.3%). Sarcopenia was significantly associated with cognitive impairment (pooled OR = 2.50, 95% CI = 1.26-4.92; p = 0.008). Heterogeneity across the studies was high and significant (I² = 84%). Discussion and Implications: Our analyzes confirmed that sarcopenic older adults presented a higher prevalence of cognitive impairment. Sarcopenia may represent a risk factor for cognitive decline, but longitudinal studies are needed to explore causality.

Indexed as

AgedAgingCognitive DysfunctionCross-Sectional StudiesFemaleHumansLongitudinal StudiesRisk FactorsSarcopeniacognitionCognitive impairmentdementiaolder adultssarcopenia

Identifiers

PMID31233073
PMCPMC12280443

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.