Evidence map›Paper›PMID 31232897›Full record

ArticleThe Pediatric infectious disease journal2019

Validation of the British Thoracic Society Severity Criteria for Pediatric Community-acquired Pneumonia.

Lilliam Ambroggio, Cole Brokamp, Rachel Mantyla, Bradley DePaoli, Richard M Ruddy, Samir S Shah, Todd A Florin

Abstract readValidation Study
In one paragraph

Article in The Pediatric infectious disease journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Proadrenomedullin Predicts Severe Disease in Children With Suspected Community-acquired Pneumonia.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lilliam AmbroggioFrom the Sections of Emergency Medicine and Hospital Medicine, Children's Hospital Colorado, Denver, Colorado.
Cole BrokampDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Rachel MantylaDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Bradley DePaoliDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Richard M RuddyDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Samir S ShahDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Todd A FlorinDepartment of Pediatrics, Northwestern University Feinberg School of Medicine.

Funding

LCenter for Clinical and Translational Science and TrainingUL1TR001425 · NCATS · UNIVERSITY OF CINCINNATI · PI HEUBI, JAMES E., KISSELA, BRETT M · 2015 to 2024
$37.5M
Ruth L. Kirschstein National Research Service Award Short-Term Institutional ReseT35HL113229 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI Raouf S. Amin, WILLIAM DAVID HARDIE · 2012 to 2026
$922k
BIOMARKERS AND RISK STRATIFICATION IN PEDIATRIC COMMUNITY-ACQUIRED PNEUMONIAK23AI121325 · NIAID · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI FLORIN, TODD ADAM · 2016 to 2019
$743k
Metabolomics Evaluation of the Etiology of PneumoniaK01AI125413 · NIAID · UNIVERSITY OF COLORADO DENVER · PI AMBROGGIO, LILLIAM · 2017 to 2021
$641k
NCATS NIH HHS UL1 TR001425NHLBI NIH HHS T35 HL113229NIAID NIH HHS K01 AI125413NIAID NIH HHS K23 AI121325
6 · The paper itself

Abstract

backgroundThe British Thoracic Society (BTS) guideline for pediatric community-acquired pneumonia (CAP) outlines severity criteria to guide clinical decision-making. Our objective was to examine the predictive performance of the criteria on the need for hospitalization (NFH) and disposition.

methodsThis was a retrospective cohort study of children 3 months-18 years of age diagnosed with CAP in an urban, pediatric emergency department (ED) in the United States from September 2014 to August 2015. Children with chronic medical conditions, recent ED visits, and ED transfers were excluded. The main outcomes were interventions or diagnoses that necessitate hospitalization (ie, NFH) and disposition (eg, admit vs. discharge). Test characteristics, stratified by age, were calculated for each outcome.

resultsOf 518 eligible children, 56.6% (n = 293) were discharged from the ED with 372 children meeting at least 1 BTS criterion. Overall BTS criteria were specific but not sensitive for NFH nor for disposition. For children <1 year of age sensitive criteria included not feeding and temperature for NFH and tachycardia, cyanosis and not feeding for disposition. For children ≥1 year of age, tachycardia had a sensitivity of >0.60 for both outcomes. The areas under the receiver operator characteristic curves for predicting any BTS criteria was 0.57 for NFH and 0.84 for disposition.

conclusionsThe BTS CAP severity criteria had fair to excellent ability to predict NFH and disposition, respectively. Although specific, the low sensitivity and poor discriminatory ability for NFH of these criteria suggest a need for improved prognostic tools for children with CAP.

Indexed as

HospitalizationSeverity of Illness IndexAdolescentChildChild, PreschoolClinical Decision-MakingCommunity-Acquired InfectionsEmergency Service, HospitalFemaleHumansInfantMalePatient DischargePneumoniaPractice Guidelines as TopicPrognosis

Identifiers

PMID31232897
PMCPMC6988639

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.