ArticleAging2019
Intermediate metabolites of the pyrimidine metabolism pathway extend the lifespan of
Article in Aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
26 citing papers in PubMed, 40 citations in OpenAlex.
- Review
- Interspecies systems biology links bacterial metabolic pathways to nematode gene expression, chemotaxis behavior, and survival.Genome research · 2025Article
- Targeting farnesoid X receptor as aging intervention therapy.Acta pharmaceutica Sinica. B · 2025Article
- ProbioticFrontiers in microbiology · 2025Article
- Multi-Omics Integrative Analysis to Reveal the Impacts ofInternational journal of molecular sciences · 2024Article
- Dendrobium Nobile Alcohol Extract Extends the Lifespan ofMolecules (Basel, Switzerland) · 2024Article
- Genetic perturbation of mitochondrial function reveals functional role for specific mitonuclear genes, metabolites, and pathways that regulate lifespan.GeroScience · 2023Article
- Effect of Kisspeptin-Type Neuropeptide on Locomotor Behavior and Muscle Physiology in the Sea CucumberAnimals : an open access journal from MDPI · 2023Article
- Systemic induction of senescence in young mice after single heterochronic blood exchange.Nature metabolism · 2022Article
- Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming.Aging cell · 2022Article
- Histone H3K4me3 modification is a transgenerational epigenetic signal for lipid metabolism in Caenorhabditis elegans.Nature communications · 2022Article
- Pioglitazone Hydrochloride Extends the Lifespan ofOxidative medicine and cellular longevity · 2022Article
- Article
- Orientin Prolongs the Longevity ofOxidative medicine and cellular longevity · 2022Article
- Metabolic drift in the aging nervous system is reflected in human cerebrospinal fluid.Scientific reports · 2021Article
- Regulation of the one carbon folate cycle as a shared metabolic signature of longevity.Nature communications · 2021Article
- Review
- MiniCAFE, a CRISPR/Cas9-based compact and potent transcriptional activator, elicits gene expression in vivo.Nucleic acids research · 2021Article
- Metabolic Responses of a Model Green MicroalgaFrontiers in bioengineering and biotechnology · 2021Article
- Exposure to dexamethasone modifies transcriptomic responses of free-living stages of Strongyloides stercoralis.PloS one · 2021Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The pyrimidine metabolism pathway has important biological functions; it not only maintains appropriate pyrimidine pools but also produces bioactive intermediate metabolites. In a previous study, we identified that the pyrimidine metabolism pathway is associated with aging regulation. However, the molecular mechanism by which the pyrimidine metabolism pathway regulates aging remains unclear. Here, we investigated the longevity effect of pyrimidine intermediates on
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.