ArticleeLife2019
Active information maintenance in working memory by a sensory cortex.
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- A Brain-wide Neuronal Spiking and Behavioral Dataset for Working Memory-specific Activation and Reactivation in Mice.Neuroscience bulletin · 2026Article
- The role of transthalamic pathways in perception.Communications biology · 2026Review
- Contextual inference through flexible integration of environmental features and behavioural outcomes.PLoS computational biology · 2026Article
- Adolescent stress exposure induces persistent, sex-specific cognitive deficits.Neurobiology of learning and memory · 2025Article
- Hierarchical Replay of Multi-regional Sequential Spiking Associated with Working Memory.Neuroscience bulletin · 2025Article
- Regulation of working memory switches from striatal dopamine D2-receptor to D1-receptor neurons under high cognitive load.PLoS biology · 2025Article
- Cortical VIP neurons as a critical node for dopamine actions.Science advances · 2025Article
- Centering cognitive neuroscience on task demands and generalization.Nature neuroscience · 2024Review
- Article
- Cell type-specific connectome predicts distributed working memory activity in the mouse brain.eLife · 2024Article
- Article
- Multitask computation through dynamics in recurrent spiking neural networks.Scientific reports · 2023Article
- Organizational Principles of the Centrifugal Projections to the Olfactory Bulb.International journal of molecular sciences · 2023Article
- Voluntary self-initiation of the stimuli onset improves working memory and accelerates visual and attentional processing.Heliyon · 2022Article
- Social defeat drives hyperexcitation of the piriform cortex to induce learning and memory impairment but not mood-related disorders in mice.Translational psychiatry · 2022Article
- Article
- Context coding in the mouse nucleus accumbens modulates motivationally relevant information.PLoS biology · 2022Article
- Decision Making in Mice During an Optimized Touchscreen Spatial Working Memory Task Sensitive to Medial Prefrontal Cortex Inactivation and NMDA Receptor Hypofunction.Frontiers in neuroscience · 2022Article
- A dopamine gradient controls access to distributed working memory in the large-scale monkey cortex.Neuron · 2021Article
- The what and when of olfactory working memory in humans.Current biology : CB · 2021Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Working memory is a critical brain function for maintaining and manipulating information over delay periods of seconds. It is debated whether delay-period neural activity in sensory regions is important for the active maintenance of information during the delay period. Here, we tackle this question by examining the anterior piriform cortex (APC), an olfactory sensory cortex, in head-fixed mice performing several olfactory working memory tasks. Active information maintenance is necessary in these tasks, especially in a dual-task paradigm in which mice are required to perform another distracting task while actively maintaining information during the delay period. Optogenetic suppression of neuronal activity in APC during the delay period impaired performance in all the tasks. Furthermore, electrophysiological recordings revealed that APC neuronal populations encoded odor information in the delay period even with an intervening distracting task. Thus, delay activity in APC is important for active information maintenance in olfactory working memory.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.