ArticleJournal of cosmetic dermatology2020
Well-aging: A new strategy for skin homeostasis under multi-stressed conditions.
Article in Journal of cosmetic dermatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Saponin from Tea (Molecules (Basel, Switzerland) · 2025Article
- What Are Topical Adaptogens? A Systematic Review and Proposed System to Identify and Categorize Skin Adaptogens in Dermatology.The Journal of clinical and aesthetic dermatology · 2025Article
- Impact of Chronic Moderate Psychological Stress on Skin Aging: Exploratory Clinical Study and Cellular Functioning.Journal of cosmetic dermatology · 2025Article
- Ectoin attenuates cortisone-induced skin issues by suppression GR signaling and the UVB-induced overexpression of 11β-HSD1.Journal of cosmetic dermatology · 2024Article
- Applying cosmetic oil with added aromatic compounds improves tactile sensitivity and skin properties.Scientific reports · 2023Article
- The Clinical Evidence-Based Paradigm of Topical Anti-Aging Skincare Formulations Enriched with Bio-Active Peptide SA1-III (KP1) as Collagen Modulator: From Bench to Bedside.Clinical, cosmetic and investigational dermatology · 2022Review
- Royal Jelly Protects against Epidermal Stress through Upregulation of the NQO1 Expression.International journal of molecular sciences · 2021Article
- Well-aging: A new strategy for skin homeostasis under multi-stressed conditions.Journal of cosmetic dermatology · 2020Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSeveral studies evidenced significant increase of cortisol is the consequence of UV or emotional stress and leads to various deleterious effects in the skin.
aimThe well-aging, a new concept of lifestyle, procures an alternative to the anti-aging strategy. We demonstrated that Tephrosia purpurea extract is able to stimulate well-being hormones while reducing cortisol release. Furthermore, we hypothesized that the extract could positively influence the global skin homeostasis.
methodWe evaluated the impact of the extract on cortisol, β-endorphin, and dopamine, released by normal human epidermal keratinocytes (NHEKs). A gene expression study was realized on NHEKs and NHDFs. The protein over-expression of HMOX1 and NQO1 was evidenced at cellular and tissue level. Finally, we conducted a clinical study on 21 women living in a polluted environment in order to observe the impact of the active on global skin improvement.
resultsThe extract is able to reduce significantly the cortisol release while inducing the production of β-endorphin and dopamine. The gene expression study revealed that Tephrosia purpurea extract up-regulated the genes involved in antioxidant response and skin renewal. Moreover, the induction of HMOX and NQO1 expression was confirmed on NHDFs, NHEKs and in RHE. We clinically demonstrated that the extract improved significantly the skin by reducing dark circles, represented by an improvement of L*, a*, and ITA parameters.
conclusionTephrosia purpurea extract has beneficial effects on skin homeostasis through control of the well-being state and antioxidant defenses leading to an improvement of dark circles, a clinical features particularly impacted by emotional and environmental stress.
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Registered trials
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