ArticleJournal of experimental botany2019
CEPR2 phosphorylates and accelerates the degradation of PYR/PYLs in Arabidopsis.
Article in Journal of experimental botany, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 92 citations in OpenAlex.
- Dry side of the core: a meta-analysis addressing the original nature of the ABA signalosome at the onset of seed imbibition.Frontiers in plant science · 2023Pooled it
- The IKU2/RLK7-MAPK-MINI3 signaling module controls endosperm cellularization timing to determine seed size in Arabidopsis.Journal of integrative plant biology · 2026Article
- Classical Phytohormones and Peptide Plant Hormones in Abiotic Stress Tolerance: Crosstalk, Physiological Integration, and Crop Improvement.Plants (Basel, Switzerland) · 2026Review
- Molecular basis of salinity stress tolerance in wheat: implications for crop resilience.Plant molecular biology · 2025Review
- SRAS1.1 E3 ligase mediates DSK2A degradation to regulate autophagy and drought tolerance in Arabidopsis.EMBO reports · 2025Article
- The TaCEP15 peptide signaling cascade modulates primary root length and drought tolerance in wheat.Science advances · 2025Article
- CEPR2 perceives group II CEPs to regulate cell surface receptor-mediated immunity in Arabidopsis.PLoS pathogens · 2025Article
- Maize leaf yellowing gene ZmCAAX modulates growth and drought resistance by regulating abscisic acid contents through interaction with the ABA biosynthetic enzyme ZmNCED3.Plant biotechnology journal · 2025Article
- Beyond nitrate transport: AtNRT2.4 responds to local and systemic nitrogen signaling in Arabidopsis.BMC plant biology · 2025Article
- Methionine as a key player in salt stress adaptation in plants.Plant physiology · 2025Article
- Unveiling the molecular mechanism underlying PSKR-mediated amplification of the ABA signaling in Arabidopsis thaliana.Plant cell reports · 2025Article
- Small peptide SiDVL/RTFLs from foxtail millet inhibit root growth through repressing auxin signaling in transgenic Arabidopsis.Plant cell reports · 2024Article
- The lowdown on breakdown: Open questions in plant proteolysis.The Plant cell · 2024Review
- MAC3A and MAC3B mediate degradation of the transcription factor ERF13 and thus promote lateral root emergence.The Plant cell · 2024Article
- Plant hormones and phenolic acids response to UV-B stress in Rhododendron chrysanthum pall.Biology direct · 2024Article
- A Genome-Wide Analysis of the CEP Gene Family in Cotton and a Functional Study ofInternational journal of molecular sciences · 2024Article
- Comprehensive Transcriptome and Metabolome Analyses Reveal Primary Molecular Regulation Pathways Involved in Peanut under Water and Nitrogen Co-Limitation.International journal of molecular sciences · 2023Article
- Transcription Factor SiDi19-3 Enhances Salt Tolerance of Foxtail Millet andInternational journal of molecular sciences · 2023Article
- Auxin promotes hypocotyl elongation by enhancing BZR1 nuclear accumulation inScience advances · 2023Article
- Maintenance of stem cell activity in plant development and stress responses.Frontiers in plant science · 2023Review
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pyrabactin resistance 1 (PYR1)/PYR1-like (PYL) abscisic acid (ABA) receptors have been proved to be recruited in the plasma membrane (PM). In order to explain the roles of PYR/PYLs in the PM, PYL4 was used as bait to screen the PM-localized leucine-rich repeat receptor-like kinase family, and five members were found directly interacting with PYL4. Loss of function by T-DNA insertion in C-terminally encoded peptide receptor 2 (CEPR2) together with phloem intercalated with xylem (PXY) and PXY-Like 2 (PXL2) led to ABA hypersensitivity, while CEPR2 overexpression led to ABA insensitivity compared with the wild type, indicating the redundant and negative roles of CEPR2, PXY, and PXL2 in ABA signaling. The PYL4 proteins were strongly accumulated in cepr2/pxy/pxl2 compared with the wild type. Furthermore, higher phosphorylation levels accompanied by lower protein levels of PYL4 in CEPR2 overexpression lines were observed, indicating the requirement of phosphorylation of PYLs for degradation. Subsequently, MS and in vitro kinase assays demonstrated that CEPR2 phosphorylated PYL4 at Ser54, while this phosphorylation was diminished or even eliminated in the presence of ABA. Taken together, CEPR2 promotes the phosphorylation and degradation of PYLs in unstressed conditions, whereas ABA represses this process to initiate ABA response during times of stress.
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