ArticleJournal of managed care & specialty pharmacy2019
The Real-World Medicare Costs of Alzheimer Disease: Considerations for Policy and Care.
Article in Journal of managed care & specialty pharmacy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The preventive efficacy of vitamin B supplements on the cognitive decline of elderly adults: a systematic review and meta-analysis.BMC geriatrics · 2021Pooled it
- Activities of Daily Living and Associated Costs in the Most Widespread Neurodegenerative Diseases: A Systematic Review.Clinical interventions in aging · 2020Pooled it
- Development of a Prediction Model for Community-Dwelling Older Adults at Risk of Long-Term Care with Dementia.Geriatrics (Basel, Switzerland) · 2026Article
- Alzheimer's disease and related dementias in rural medicare populations: a scoping review.BMC geriatrics · 2026Article
- Relationships of change in Clinical Dementia Rating (CDR) on patient outcomes and probability of progression: observational analysis.Alzheimer's research & therapy · 2024Article
- Cost of care for Alzheimer's disease and related dementias in the United States: 2016 to 2060.npj aging · 2024Article
- Economic Impact of Progression from Mild Cognitive Impairment to Alzheimer Disease in the United States.The journal of prevention of Alzheimer's disease · 2024Article
- Alteration of Blood Immune Biomarkers in MCI Patients with DifferentInternational journal of molecular sciences · 2023Article
- Public spending on acute and long-term care for Alzheimer's disease and related dementias.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Evaluating The Accuracy Of Medicare Risk Adjustment For Alzheimer's Disease And Related Dementias.Health affairs (Project Hope) · 2022Article
- The Humanistic and Economic Burden of Alzheimer's Disease.Neurology and therapy · 2022Review
- Cost-effectiveness of Aducanumab and Donanemab for Early Alzheimer Disease in the US.JAMA neurology · 2022Article
- Trends in US Medicare Decedents' Diagnosis of Dementia From 2004 to 2017.JAMA health forum · 2022Article
- Exploring costs, cost components, and associated factors among people with dementia approaching the end of life: A systematic review.Alzheimer's & dementia (New York, N. Y.) · 2021Review
- Residential Setting and the Cumulative Financial Burden of Dementia in the 7 Years Before Death.Journal of the American Geriatrics Society · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHeadlines in popular media suggest that Alzheimer disease will bankrupt the Medicare program. Indeed, Alzheimer disease affects more than 5 million older Medicare beneficiaries.
objectiveTo compare total Medicare-covered (allowed) costs of patients with Alzheimer disease with the risk adjusted costs of beneficiaries without dementia over their last years of life, using claims data.
methodsUsing the Medicare 5 Percent Limited Data Set claim files from 2006-2015, we conducted a cost impact analysis of costs for up to 8 years before the year of death. Risk adjustment was performed at a beneficiary level using Medicare's 2015 Hierarchical Condition Categories. Beneficiaries were classified into dementia categories based on their diagnoses during the last 3 years of life. Costs were trend adjusted to 2015.
resultsThis study found that 40% of deceased beneficiaries have Alzheimer disease or unspecified dementia diagnoses in their claims history. In their last 9 years of life, Alzheimer disease added about 11% to the average $17,000 per year Medicare cost for same-risk beneficiaries without dementia.
conclusionsLike many diseases, Alzheimer disease and dementia are associated with aging, but unlike other diseases, families and Medicaid, rather than Medicare, bear most of the substantial cost burden. As research continues into Alzheimer treatments, it is not too early to consider how to better integrate Medicare and Medicaid to fund and improve patient outcomes, which will likely involve better diagnosis, treatment, and care coordination. DISCLOSURES: Funding for this project was provided by the Alliance for Aging Research, which received funding from Biogen, Eli Lilly, and Janssen Pharmaceuticals. Peschin and Jenkins are employed by the Alliance for Aging Research. Scott was employed by the Alliance for Aging Research at the time of this study and also reports consulting fees from Piramal Imaging, General Electric, and Allergan, outside of this study. Scott is chair of the Board of Directors for the Alliance for Aging Research, which is a volunteer position, and is also president of Applied Policy, a health policy and reimbursement consultancy. Pyenson and Steffens are employed by Milliman, which was contracted to work on this study. Goss Sawhney and Rotter were employed by Milliman at the time this work was performed. Milliman is a consultant to thousands of organizations in the health care industry.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.