ReviewCellular microbiology2019
Bartonella gene transfer agent: Evolution, function, and proposed role in host adaptation.
Review in Cellular microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 38 citations in OpenAlex.
- Perturbations shift the composition of bacterial DNA carried by virus-like particles in the murine gut microbiome.bioRxiv : the preprint server for biology · 2026Article
- Description ofInternational journal of systematic and evolutionary microbiology · 2026Article
- Large-scale capsid-mediated mobilisation of bacterial genomic DNA in the gut microbiome.Nature communications · 2026Article
- The prevalence and genetic diversity of Bartonella species in wild rodents from South Korea.Scientific reports · 2025Article
- Gene transfer agents: The ambiguous role of selfless viruses in genetic exchange and bacterial evolution.Molecular microbiology · 2025Review
- Sneaky tactics: Ingenious immune evasion mechanisms ofVirulence · 2024Review
- Pathogen contingency loci and the evolution of host specificity: Simple sequence repeats mediate Bartonella adaptation to a wild rodent host.PLoS pathogens · 2024Article
- Sequence typing of Bartonella henselae in small Indian mongooses (Urva auropunctata).Scientific reports · 2024Article
- Evaluation of the available animal models forOne health (Amsterdam, Netherlands) · 2024Review
- A novelmSystems · 2024Article
- IsLeukemia research reports · 2024Review
- Bartonella infections are prevalent in rodents despite efficient immune responses.Parasites & vectors · 2023Article
- Virus-like Particles fromInsects · 2023Article
- Two novelFrontiers in microbiology · 2023Article
- Loss of the Rhodobacter capsulatus Serine Acetyl Transferase Gene,Applied and environmental microbiology · 2022Article
- The archetypal gene transfer agent RcGTA is regulated via direct interaction with the enigmatic RNA polymerase omega subunit.Cell reports · 2022Article
- Gene Transfer Agents in Bacterial Endosymbionts of Microbial Eukaryotes.Genome biology and evolution · 2022Article
- Identification of theProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Adaptive immune defense prevents Bartonella persistence upon trans-placental transmission.PLoS pathogens · 2022Article
- Femtoplankton: What's New?Viruses · 2020Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The processes underlying host adaptation by bacterial pathogens remain a fundamental question with relevant clinical, ecological, and evolutionary implications. Zoonotic pathogens of the genus Bartonella constitute an exceptional model to study these aspects. Bartonellae have undergone a spectacular diversification into multiple species resulting from adaptive radiation. Specific adaptations of a complex facultative intracellular lifestyle have enabled the colonisation of distinct mammalian reservoir hosts. This remarkable host adaptability has a multifactorial basis and is thought to be driven by horizontal gene transfer (HGT) and recombination among a limited genus-specific pan genome. Recent functional and evolutionary studies revealed that the conserved Bartonella gene transfer agent (BaGTA) mediates highly efficient HGT and could thus drive this evolution. Here, we review the recent progress made towards understanding BaGTA evolution, function, and its role in the evolution and pathogenesis of Bartonella spp. We notably discuss how BaGTA could have contributed to genome diversification through recombination of beneficial traits that underlie host adaptability. We further address how BaGTA may counter the accumulation of deleterious mutations in clonal populations (Muller's ratchet), which are expected to occur through the recurrent transmission bottlenecks during the complex infection cycle of these pathogens in their mammalian reservoir hosts and arthropod vectors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.