Evidence map›Paper›PMID 31231935›Full record

ArticleJournal of peptide science : an official publication of the European Peptide Society2019

Amyloidogenicity of naturally occurring full-length animal IAPP variants.

Larry M Palato, Shannon Pilcher, Alissa Oakes, Arleen Lamba, Jaris Torres, Litza I Ledesma Monjaraz, Crystabel Munoz, Edward Njoo, Dillon J Rinauro, Kate Alexandra Menefee and 9 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of peptide science : an official publication of the European Peptide Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
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  10. Article
  11. The Role of Glycation on the Aggregation Properties of IAPP.Frontiers in molecular biosciences · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 2 institutions in 1 country.

Larry M PalatoDepartment of Chemistry and Biochemistry, Loyola Marymount University, Los Angeles, CA.
Shannon PilcherDepartment of Chemistry and Biochemistry, Loyola Marymount University, Los Angeles, CA.
Alissa OakesDepartment of Biology, Mount Saint Mary's University, Los Angeles, CA.
Arleen LambaDepartment of Biology, Mount Saint Mary's University, Los Angeles, CA.
Jaris TorresDepartment of Biology, Mount Saint Mary's University, Los Angeles, CA.
Litza I Ledesma MonjarazDepartment of Biology, Mount Saint Mary's University, Los Angeles, CA.
Crystabel MunozDepartment of Biology, Mount Saint Mary's University, Los Angeles, CA.
Edward NjooDepartment of Chemistry and Biochemistry, Loyola Marymount University, Los Angeles, CA.
Dillon J RinauroDepartment of Chemistry and Biochemistry, Loyola Marymount University, Los Angeles, CA.
Kate Alexandra MenefeeDepartment of Chemistry and Biochemistry, Loyola Marymount University, Los Angeles, CA.
Angela TunDepartment of Chemistry and Biochemistry, Loyola Marymount University, Los Angeles, CA.
Betssy L JaureguiDepartment of Chemistry and Biochemistry, Loyola Marymount University, Los Angeles, CA.
Sarah ShapiroDepartment of Chemistry and Biochemistry, Loyola Marymount University, Los Angeles, CA.
Olivia H NossiffDepartment of Chemistry and Biochemistry, Loyola Marymount University, Los Angeles, CA.
Eileen OlivaresDepartment of Chemistry and Biochemistry, Loyola Marymount University, Los Angeles, CA.
Kevin ChangDepartment of Chemistry and Biochemistry, Loyola Marymount University, Los Angeles, CA.
Viviane NguyenDepartment of Chemistry and Biochemistry, Loyola Marymount University, Los Angeles, CA.
Luiza A NogajDepartment of Biology, Mount Saint Mary's University, Los Angeles, CA.ORCID https://orcid.org/0000-0001-7137-3494
David A MoffetDepartment of Chemistry and Biochemistry, Loyola Marymount University, Los Angeles, CA.ORCID https://orcid.org/0000-0002-7430-861X
Loyola Marymount University · USMount St. Mary's University · US

Funding

Optimizing Peptide Inhibitors of Human Iapp Amyloidogenicity and Identifying their Effects on the Unfolded Protein Response SystemR15DK112172 · NIDDK · LOYOLA MARYMOUNT UNIVERSITY · PI MOFFET, DAVID AARON, NOGAJ, LUIZA ANNA · 2016 to 2019
$800k
National Institute of Diabetes and Digestive and Kidney Diseases R15DK112172National Institutes of Health R15DK112172NIDDK NIH HHS R15 DK112172
6 · The paper itself

Abstract

The aggregation of the 37-amino acid polypeptide human islet amyloid polypeptide (hIAPP), as either insoluble amyloid or as small oligomers, appears to play a direct role in the death of human pancreatic β-islet cells in type 2 diabetes. hIAPP is considered to be one of the most amyloidogenic proteins known. The quick aggregation of hIAPP leads to the formation of toxic species, such as oligomers and fibers, that damage mammalian cells (both human and rat pancreatic cells). Whether this toxicity is necessary for the progression of type 2 diabetes or merely a side effect of the disease remains unclear. If hIAPP aggregation into toxic amyloid is on-path for developing type 2 diabetes in humans, islet amyloid polypeptide (IAPP) aggregation would likely need to play a similar role within other organisms known to develop the disease. In this work, we compared the aggregation potential and cellular toxicity of full-length IAPP from several diabetic and nondiabetic organisms whose aggregation propensities had not yet been determined for full-length IAPP.

Indexed as

AnimalsCatsCattleCell Line, TumorCell SurvivalChickensDogsDose-Response Relationship, DrugGuinea PigsHumansIslet Amyloid PolypeptideOctodonRaccoonsRatsStructure-Activity RelationshipSwineIslet Amyloid Polypeptideamylinamyloidprotein aggregationtype 2 diabetes

Identifiers

PMID31231935
PMCPMC6639132
OpenAlexW2955947296

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.