Evidence map›Paper›PMID 31231869›Full record

ArticleJournal of neuroendocrinology2019

Prolactin receptor expression in mouse dorsal root ganglia neuronal subtypes is sex-dependent.

Mayur Patil, Anahit H Hovhannisyan, Andi Wangzhou, Jennifer Mecklenburg, Wouter Koek, Vincent Goffin, David Grattan, Ulrich Boehm, Gregory Dussor, Theodore J Price and 1 more

Open access · greenAbstract read
In one paragraph

Article in Journal of neuroendocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.

  1. Prolactin and pain of endometriosis.Pharmacology & therapeutics · 2023
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. A prolactin-targeting antibody to prevent stress-induced peripheral nociceptor sensitization and female postoperative pain.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. A Female-Specific Role for Calcitonin Gene-Related Peptide (CGRP) in Rodent Pain Models.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  18. Article
  19. A prolactin-dependent sexually dimorphic mechanism of migraine chronification.Cephalalgia : an international journal of headache · 2022
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 4 countries.

Mayur PatilDepartment of Endodontics, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Anahit H HovhannisyanDepartment of Endodontics, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Andi WangzhouSchool of Behavioral and Brain Sciences and Center for Advanced Pain Studies, University of Texas at Dallas, Richardson, TX, USA.
Jennifer MecklenburgDepartment of Endodontics, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Wouter KoekDepartment of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Vincent GoffinInserm U1151, Université Paris Descartes, Paris, France.
David GrattanCentre for Neuroendocrinology and Department of Anatomy, University of Otago School of Biomedical Sciences, Dunedin, New Zealand.ORCID 0000-0001-5606-2559
Ulrich BoehmDepartment of Pharmacology and Toxicology, Center for Molecular Signaling (PZMS), Saarland University School of Medicine, Homburg, Germany.
Gregory DussorSchool of Behavioral and Brain Sciences and Center for Advanced Pain Studies, University of Texas at Dallas, Richardson, TX, USA.
Theodore J PriceSchool of Behavioral and Brain Sciences and Center for Advanced Pain Studies, University of Texas at Dallas, Richardson, TX, USA.
Armen N AkopianDepartment of Endodontics, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.ORCID 0000-0002-1066-253X
The University of Texas Health Science Center at San Antonio · USThe University of Texas at Dallas · USDélégation Paris 5 · FRSaarland University · DEUniversity of Otago · NZ

Funding

Translation Control of Pain PlasticityR01NS065926 · NINDS · UNIVERSITY OF TEXAS DALLAS · PI PRICE, THEODORE J. · 2010 to 2023
$5.7M
Sex-specific regulation of local translation and chronic pain mechanisms in femalesR01NS102161 · NINDS · UNIVERSITY OF TEXAS DALLAS · PI AKOPIAN, ARMEN N, PRICE, THEODORE J. · 2018 to 2022
$2.5M
Meningeal prolactin signaling and female-selective migraine mechanismsR01NS104200 · NINDS · UNIVERSITY OF TEXAS DALLAS · PI AKOPIAN, ARMEN N, DUSSOR, GREGORY O · 2018 to 2022
$2.4M
Prolactin Regulation of Trigeminal NociceptorsR01DE017696 · NIDCR · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI AKOPIAN, ARMEN N · 2007 to 2011
$1.8M
Prolactin regulation of postoperative pain in males and femalesR01GM112747 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI AKOPIAN, ARMEN N · 2015 to 2018
$1.2M
NIDCR NIH HHS R01 DE017696NIGMS NIH HHS R01 GM112747NINDS NIH HHS R01 NS065926NINDS NIH HHS R01 NS102161NINDS NIH HHS R01 NS104200
6 · The paper itself

Abstract

Sensory neurones exhibit sex-dependent responsiveness to prolactin (PRL). This could contribute to sexual dimorphism in pathological pain conditions. The present study aimed to determine the mechanisms underlying sex-dependent PRL sensitivity in sensory neurones. A quantitative reverse transcriptase-polymerase chain reaction shows that prolactin receptor (Prlr) long and short isoform mRNAs are expressed at comparable levels in female and male mouse dorsal root ganglia (DRG). In Prlr

Indexed as

AnimalsCells, CulturedFemaleGanglia, SpinalGene ExpressionMaleMiceMice, 129 StrainMice, Inbred C57BLMice, TransgenicNeuronsReceptors, ProlactinSex CharacteristicsReceptors, Prolactinelectrophysiologynociceptionprolactinprolactin receptorsensory neurones

Identifiers

PMID31231869
PMCPMC6939775
OpenAlexW2955415153

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.