ArticleJournal of clinical laboratory analysis2019
Impact of different Streptococcus pneumoniae on the secretion of interleukin and adhesin from THP-1 monocytes.
Article in Journal of clinical laboratory analysis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 1 citations in OpenAlex.
- Analysis of clinical characteristics of 92 patients with paroxysmal nocturnal hemoglobinuria: A single institution experience in China.Journal of clinical laboratory analysis · 2020Article
- Impact of different Streptococcus pneumoniae on the secretion of interleukin and adhesin from THP-1 monocytes.Journal of clinical laboratory analysis · 2019Article
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Authors and funding
8 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundTo investigate the secretion of interleukin-1β (IL-1β), IL-6, IL-10, IL-8, and soluble intercellular adhesin molecule 1 (sICAM-1) from THP-1 monocytes stimulated by different Streptococcus pneumoniae (S pneumoniae) strains.
methodsFifty-eight strains of S pneumoniae were collected: ATCC49619, 23 from sputum (sd-SP), 23 from blood (bd-SP), and 11 from cerebrospinal fluid (CSF; cd-SP). Such strains were cultured and suspended at 0.5 McFarland. THP-1 monocytes were cultured and resuspended at 5.0 × 10
resultsContrary to IL-10, the concentrations of IL-1β, IL-6, IL-8, and sICAM-1 all increased first and then decreased. IL-1β and sICAM-1 levels in the ATCC49619 group were both higher than all the clinical S pneumoniae groups (sd-SP, bd-SP, and cd-SP), IL-6 and IL-8 versa, and IL-10 equal. The difference among clinical S pneumoniae groups lay only in sICAM-1. cd-SP group showed lower sICAM-1 concentrations than sd-SP and bd-SP groups at both 4 and 8 hours. However, they became equal at 12 hours.
conclusionsThe secretion summit is 8 hours for IL-1β, IL-6, IL-8, and sICAM-1, bottom for IL-10. Different clinical S pneumoniae strains show similar ability to induce THP-1 cells secreting interleukins. However, cd-SP induces THP-1 cells secreting lower sICAM-1 than sd-SP and bd-SP, which may in turn facilitate its invasion into CSF.
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