ReviewAnnals of the New York Academy of Sciences2019
Hemoglobin concentration and anemia diagnosis in venous and capillary blood: biological basis and policy implications.
Review in Annals of the New York Academy of Sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
73 citing papers in PubMed, 2 syntheses or guidelines pooled it, 120 citations in OpenAlex.
- Daily oral iron supplementation during pregnancy.The Cochrane database of systematic reviews · 2024Pooled it
- Associations between type of blood collection, analytical approach, mean haemoglobin and anaemia prevalence in population-based surveys: A systematic review and meta-analysis.Journal of global health · 2022Pooled it
- Impacts of a Homestead Food Production Intervention on Anaemia and Micronutrient Deficiencies Among Women and Children in Rural Bangladesh: A Cluster-Randomized Controlled Trial.Maternal & child nutrition · 2025Trial
- Comparing HemoCue® and Quantitative Buffy Coat® and Coulter Counter-measured haemoglobin concentrations in African children with acute uncomplicated malaria: a Bland-Altman analysis.Malaria journal · 2025Trial
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- Strong concordance of DNA methylation measures between venous and capillary blood - Implications for human epigenome studies.iScience · 2026Article
- Comparison of capillary and venous hemoglobin determination among school-age children: insights from Zanzibar, Tanzania.Advances in laboratory medicine · 2026Article
- Child Hemoglobin Trajectories across the First 10 Years of Life and Association with Child Cognition and Academic Achievement at 10-11 Years.The Journal of nutrition · 2026Article
- Haemoglobin concentration thresholds that discriminate functional outcomes among children aged 6-30 months in eight countries: a pooled analysis of individual participant data.BMJ global health · 2026Article
- The nationwide prevalence of anaemia and the associated factors in the general adult population in Malaysia.BMC public health · 2026Article
- Clinical perspectives on hemoglobin measurement: The example of malaria radical cure.PLOS global public health · 2026Article
- Evaluation of point-of-care hemoglobin testing vs. central laboratory measurements in neonates: a prospective study in neonatal intensive care unit.Frontiers in pediatrics · 2026Article
- Validation of HemoCue method and development of a revised hemoglobin cut-off to detect anemia in children aged 6-24-months.PloS one · 2026Article
- Method Comparison and Investigation of Interference Variables of a Hand-Held Hemoglobinometer(HemoCue Hb 201Veterinary clinical pathology · 2025Article
- Sex-specific hemoglobin thresholds and longitudinal trajectories in intracerebral hemorrhage outcomes: a multicenter cohort study.BMC neurology · 2025Article
- The Association Between Hematological Profiles and Whole-Blood Transcriptome Genes Identified Using Quantitative Analysis with Average Daily Gain and Feed Efficiency in Forage-Fed Beef Heifers.International journal of molecular sciences · 2025Article
- Anaemia and iron deficiency in India: a venous blood-based survey of adolescents, adults, and the elderly in eight states.European journal of clinical nutrition · 2025Article
- Non-invasive quantification of total hemoglobin concentrations by visible-light spectroscopic optical coherence tomography: a validation study on healthy volunteers.Biomedical optics express · 2025Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 6 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anemia is an important public health challenge and accurate prevalence estimates are needed for program planning and tracking progress. While venous blood assessed by automated hematology analyzers is considered gold standard, most population-based surveys use point-of-care diagnostics and capillary blood to estimate population prevalence of anemia. Several factors influence hemoglobin (Hb) concentration, including human and analytic error, analysis method, and type of instrument, but it is unclear whether biological variability exists between venous and capillary blood. The objective of this paper was to systematically review sources of Hb variability and the potential biological basis for venous and capillary differences. We use data from a recent survey in the state of Uttar Pradesh, India, to illustrate the implications on anemia prevalence estimates. Significant differences in Hb concentration between capillary and venous blood samples are common. Most but not all find capillary Hb concentration to be higher than venous. Instrument/method variability and human error play an important role, but cannot fully explain these differences. A normative guide to data collection, analysis, and anemia diagnosis is needed to ensure consistent and appropriate interpretation. Further research is needed to fully understand the biological implications of venous and capillary Hb variability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.