Evidence map›Paper›PMID 31231758›Full record

Trial reportThe journals of gerontology. Series A, Biological sciences and medical sciences2020

A Single Dose of Dietary Nitrate Increases Maximal Knee Extensor Angular Velocity and Power in Healthy Older Men and Women.

Andrew R Coggan, Richard L Hoffman, Derrick A Gray, Ranjani N Moorthi, Deepak P Thomas, Joshua L Leibowitz, Dakkota Thies, Linda R Peterson

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The journals of gerontology. Series A, Biological sciences and medical sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 5 pooled it
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 5 syntheses or guidelines pooled it, 57 citations in OpenAlex.

  1. Pooled it
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  7. Dietary nitrate and muscle contractile function in women: effect of menstrual cycle phase.Journal of applied physiology (Bethesda, Md. : 1985) · 2026
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  15. Dose-Response Effect of Dietary Nitrate on Muscle Contractility and Blood Pressure in Older Subjects: A Pilot Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Andrew R CogganDepartment of Kinesiology, Indiana University-Purdue University Indianapolis.
Richard L HoffmanDepartment of Kinesiology, Indiana University-Purdue University Indianapolis.
Derrick A GrayDepartment of Kinesiology, Indiana University-Purdue University Indianapolis.
Ranjani N MoorthiDepartment of Internal Medicine, Indiana University-Purdue University Indianapolis.
Deepak P ThomasDepartment of Medicine, Washington University School of Medicine, St. Louis, Missouri.
Joshua L LeibowitzDepartment of Medicine, Washington University School of Medicine, St. Louis, Missouri.
Dakkota ThiesDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri.
Linda R PetersonDepartment of Medicine, Washington University School of Medicine, St. Louis, Missouri.
Indiana University – Purdue University Indianapolis · USWashington University in St. Louis · US

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Washington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Brian N Finck · 1999 to 2026
$30.2M
Quality Assurance and Quality Control Project Management: Improving Submissions and Study Conduct in the Human Subjects Research Prior Approval ProcessUL1TR002529 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M, WIEHE, SARAH ELIZABETH · 2018 to 2022
$27.2M
Resource CoreP30AR072581 · NIAMS · INDIANA UNIVERSITY INDIANAPOLIS · PI Sharon M Moe · 2017 to 2026
$8.3M
Longitudinal Assessment of Skeletal Muscle Physiology in Dialysis PatientsK23DK102824 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI MOORTHI, RANJANI N. · 2015 to 2019
$892k
THE INORGANIC NITRATE FOR EXERCISE IN HEART FAILURE (INIX-HF) TRIALR34HL138253 · NHLBI · WASHINGTON UNIVERSITY · PI COGGAN, ANDREW R, PETERSON, LINDA RUTH · 2017 to 2019
$701k
Dietary Nitrate and Muscle Power with AgingR21AG053606 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI COGGAN, ANDREW R · 2018 to 2019
$433k
NCATS NIH HHS UL1 TR002345NCATS NIH HHS UL1 TR002529NHLBI NIH HHS R34 HL138253NIAMS NIH HHS P30 AR072581NIA NIH HHS R21 AG053606NIDDK NIH HHS K23 DK102824NIDDK NIH HHS P30 DK056341
6 · The paper itself

Abstract

backgroundAging results in reductions in maximal muscular strength, speed, and power, which often lead to functional limitations highly predictive of disability, institutionalization, and mortality in elderly adults. This may be partially due to reduced nitric oxide (NO) bioavailability. We, therefore, hypothesized that dietary nitrate (NO3-), a source of NO via the NO3- → nitrite (NO2-) → NO enterosalivary pathway, could increase muscle contractile function in older subjects.

methodsTwelve healthy older (age 71 ± 5 years) men and women were studied using a randomized, double-blind, placebo-controlled, crossover design. After fasting overnight, subjects were tested 2 hours after ingesting beetroot juice containing or devoid of 13.4 ± 1.6 mmol NO3-. Plasma NO3- and NO2- and breath NO were measured periodically, and muscle function was determined using isokinetic dynamometry.

resultsN O 3 - ingestion increased (p < .001) plasma NO3-, plasma NO2-, and breath NO by 1,051% ± 433%, 138% ± 149%, and 111% ± 115%, respectively. Maximal velocity of knee extension increased (p < .01) by 10.9% ± 12.1%. Maximal knee extensor power increased (p < .05) by 4.4% ± 7.8%.

conclusionsAcute dietary NO3- intake improves maximal knee extensor angular velocity and power in older individuals. These findings may have important implications for this population, in whom diminished muscle function can lead to functional limitations, dependence, and even premature death.

Indexed as

AgedDietary SupplementsDouble-Blind MethodFemaleHumansKneeMaleMovementMuscle ContractionMuscle StrengthMuscle Strength DynamometerNitratesNitratesBlood pressureIsokinetic dynamometryNitric oxideNitrite

Identifiers

PMID31231758
PMCPMC7243590
OpenAlexW2956052777

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.